Preconditioning: The mitochondrial connection

Elizabeth Murphy, Charles Steenbergen

Research output: Contribution to journalReview articlepeer-review

181 Scopus citations


Over the past decade there has been considerable progress in elucidating the signaling pathways involved in cardioprotection. Considerable recent data suggest that many of these signaling pathways converge on the mitochondria, where such pathways alter the activity of key mitochondrial proteins, leading to reduced apoptosis and necrosis. Inhibition of the mitochondrial permeability transition pore is emerging as a central mechanism in cardioprotection. This review focuses on mechanisms by which cardioprotection alters mitochondrial proteins and channels that regulate cell death and survival.

Original languageEnglish (US)
Pages (from-to)51-67
Number of pages17
JournalAnnual review of physiology
StatePublished - 2007


  • Glycogen synthase kinase
  • Mitochondrial permeability transition
  • Protein kinase C
  • Voltage-dependent anion channel

ASJC Scopus subject areas

  • Physiology


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