Preconception and prenatal factors and metabolic risk

Guoying Wang, Tami R. Bartell, Xiaobin Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The prenatal period is a critical developmental stage for obesity and metabolic outcomes. In light of the global obesity and type 2 diabetes (T2DM) epidemic and growing evidence of early life origins of obesity and diabetes, early identification of individuals at high risk and early prevention of obesity and metabolic syndrome are a key to achieve primary prevention and reverse the trends of the obesity and T2DM epidemics. This chapter will discuss the impact of important preconceptional and prenatal factors, including maternal obesity and/or diabetes, gestational weight gain, and maternal micronutrient status, on in utero and lifelong metabolic outcomes and the possible gene-environment interactions and epigenetic mechanisms underlying early life origins of metabolic risk. Finally, it will provide perspectives on current knowledge gaps and recommendations to advance the field.

Original languageEnglish (US)
Title of host publicationHandbook of Life Course Health Development
PublisherSpringer International Publishing
Number of pages13
ISBN (Electronic)9783319471433
ISBN (Print)9783319471419
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Psychology(all)
  • Social Sciences(all)
  • Economics, Econometrics and Finance(all)
  • Business, Management and Accounting(all)
  • Medicine(all)


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