Precocious puberty in a boy with hepatoma and circulating gonadotropin

W. Hung, R. M. Blizzard, C. J. Migeon, A. M. Camacho, W. L. Nyhan

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Sexual precocity resulting from circulating gonadotropin is reported in a 2-year-old child with hepatoblastoma. Following removal of the tumor the sexual precocity regressed and the gonadotropin in the serum disappeared. The patient eventually succumbed to his disease as have the other four similar patients that have been reported upon. This unusual cause of sexual precocity must be considered in the differential diagnosis of isosexual precocity. The clinical signs and symptoms, and the chemical abnormalities that occur in patients of this type, are discussed.

Original languageEnglish (US)
Pages (from-to)895-903
Number of pages9
JournalThe Journal of pediatrics
Issue number5
StatePublished - Nov 1963

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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