Preclinical MRI-Guided Focused Ultrasound: A Review of Systems and Current Practices

Nicholas P.K. Ellens, Ari Partanen

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Effective preclinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review, we seek to outline the challenges at hand for effective preclinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated preclinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research. Specifically, we examine additional hardware that has been used to adapt clinical MRgFUS equipment to better position, constrain, and image preclinical subjects, as well as software solutions that have been used to extend the potential and capabilities of clinical devices.

Original languageEnglish (US)
Pages (from-to)291-305
Number of pages15
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number1
StatePublished - Jan 2017


  • Biomedical applications of radiation
  • biomedical transducers
  • ultrasonic transducers

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering


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