TY - JOUR
T1 - Preclinical abortions
T2 - Incidence and significance in the Norfolk in vitro fertilization program
AU - Acosta, A. A.
AU - Oehninger, S.
AU - Hammer, J.
AU - Muasher, S. J.
AU - Liang, H. M.
AU - Jones, D. L.
PY - 1990
Y1 - 1990
N2 - Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum β-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.
AB - Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum β-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.
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U2 - 10.1016/s0015-0282(16)53462-1
DO - 10.1016/s0015-0282(16)53462-1
M3 - Article
C2 - 2318326
AN - SCOPUS:0025329641
SN - 0015-0282
VL - 53
SP - 673
EP - 676
JO - Fertility and sterility
JF - Fertility and sterility
IS - 4
ER -