@article{05496bab23ef45908715c8210524d1cc,
title = "Precision medicine in pediatric oncology: Lessons learned and next steps",
abstract = "The maturation of genomic technologies has enabled new discoveries in disease pathogenesis as well as new approaches to patient care. In pediatric oncology, patients may now receive individualized genomic analysis to identify molecular aberrations of relevance for diagnosis and/or treatment. In this context, several recent clinical studies have begun to explore the feasibility and utility of genomics-driven precision medicine. Here, we review the major developments in this field, discuss current limitations, and explore aspects of the clinical implementation of precision medicine, which lack consensus. Lastly, we discuss ongoing scientific efforts in this arena, which may yield future clinical applications.",
keywords = "next-generation sequencing, oncology, precision medicine, targeted therapy",
author = "Mody, {Rajen J.} and Prensner, {John R.} and Jessica Everett and Parsons, {D. Williams} and Chinnaiyan, {Arul M.}",
note = "Funding Information: The authors would like to thank Karen Giles for administrative support and Kevin Frank for helping with formatting the manuscript, figures, and tables. The BASIC3 and PEDS-MIONCOSEQ studies are Clinical Sequencing Exploratory Research program projects supported by the National Human Genome Research Institute and the National Cancer Institute (U01HG006485 and UM1HG006508, respectively). RJM is supported by the Hyundai Hope on Wheels Scholar Award. AMC is supported by the Doris Duke Charitable Foundation Clinical Scientist Award, Prostate Cancer Foundation, and Howard Hughes Medical Institute. AMC is an American Cancer Society Research Professor and a Taubman Scholar of the University of Michigan. The authors declare that there is no conflict of interest. Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = mar,
day = "1",
doi = "10.1002/pbc.26288",
language = "English (US)",
volume = "64",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "3",
}