Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells

Min Seong Kim; Hyesoo Kim; Gabsang Lee

doi:10.1002/adhm.202303041

Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells

Min Seong Kim, Hyesoo Kim, Gabsang Lee

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Parkinson's disease (PD) is one of the most devastating neurological diseases; however, there is no effective cure yet. The availability of human induced pluripotent stem cells (iPSCs) provides unprecedented opportunities to understand the pathogenic mechanism and identification of new therapy for PD. Here a new model system of PD, including 2D human iPSC-derived midbrain dopaminergic (mDA) neurons, 3D iPSC-derived midbrain organoids (MOs) with cellular complexity, and more advanced microphysiological systems (MPS) with 3D organoids, is introduced. It is believed that successful integrations and applications of iPSC, organoid, and MPS technologies can bring new insight on PD's pathogenesis that will lead to more effective treatments for this debilitating disease.

Original language	English (US)
Article number	2303041
Journal	Advanced Healthcare Materials
Volume	13
Issue number	21
DOIs	https://doi.org/10.1002/adhm.202303041
State	Published - Aug 21 2024

Keywords

Parkinson's disease
induced pluripotent stem cells
microphysiological systems
midbrain organoids

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.202303041

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title = "Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells",

abstract = "Parkinson's disease (PD) is one of the most devastating neurological diseases; however, there is no effective cure yet. The availability of human induced pluripotent stem cells (iPSCs) provides unprecedented opportunities to understand the pathogenic mechanism and identification of new therapy for PD. Here a new model system of PD, including 2D human iPSC-derived midbrain dopaminergic (mDA) neurons, 3D iPSC-derived midbrain organoids (MOs) with cellular complexity, and more advanced microphysiological systems (MPS) with 3D organoids, is introduced. It is believed that successful integrations and applications of iPSC, organoid, and MPS technologies can bring new insight on PD's pathogenesis that will lead to more effective treatments for this debilitating disease.",

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AB - Parkinson's disease (PD) is one of the most devastating neurological diseases; however, there is no effective cure yet. The availability of human induced pluripotent stem cells (iPSCs) provides unprecedented opportunities to understand the pathogenic mechanism and identification of new therapy for PD. Here a new model system of PD, including 2D human iPSC-derived midbrain dopaminergic (mDA) neurons, 3D iPSC-derived midbrain organoids (MOs) with cellular complexity, and more advanced microphysiological systems (MPS) with 3D organoids, is introduced. It is believed that successful integrations and applications of iPSC, organoid, and MPS technologies can bring new insight on PD's pathogenesis that will lead to more effective treatments for this debilitating disease.

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Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells

Abstract

Keywords

ASJC Scopus subject areas

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