Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases

Yael Eshed-Eisenbach; Jerome Devaux; Anna Vainshtein; Ofra Golani; Se Jin Lee; Konstantin Feinberg; Natasha Sukhanov; Daniel S. Greenspan; Keiichiro Susuki; Matthew N. Rasband; Elior Peles

doi:10.1016/j.neuron.2020.03.001

Precise Spatiotemporal Control of Nodal Na⁺ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases

Yael Eshed-Eisenbach
, Jerome Devaux
, Anna Vainshtein
, Ofra Golani
, Se Jin Lee
, Konstantin Feinberg
, Natasha Sukhanov
, Daniel S. Greenspan
, Keiichiro Susuki
, Matthew N. Rasband
, Elior Peles

Research output: Contribution to journal › Article › peer-review

Abstract

Eshed-Eisenbach et al. demonstrate that BMP1/Tll1-mediated cleavage of gliomedin provides a regulatory mechanism ensuring that Na⁺ channels are clustered at the right time and place during PNS development. By negatively regulating the activity of gliomedin, these enzymes couple between myelination and clustering of Na⁺ channels at the nodes of Ranvier.

Original language	English (US)
Pages (from-to)	806-815.e6
Journal	Neuron
Volume	106
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2020.03.001
State	Published - Jun 3 2020
Externally published	Yes

Keywords

Axon-glia interaction
ECM
Gliomedin
Myelin
Neurofascin
Node of Ranvier
PNS development
Schwann cells
Sodium channels

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2020.03.001

Cite this

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title = "Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases",

abstract = "Eshed-Eisenbach et al. demonstrate that BMP1/Tll1-mediated cleavage of gliomedin provides a regulatory mechanism ensuring that Na+ channels are clustered at the right time and place during PNS development. By negatively regulating the activity of gliomedin, these enzymes couple between myelination and clustering of Na+ channels at the nodes of Ranvier.",

keywords = "Axon-glia interaction, ECM, Gliomedin, Myelin, Neurofascin, Node of Ranvier, PNS development, Schwann cells, Sodium channels",

author = "Yael Eshed-Eisenbach and Jerome Devaux and Anna Vainshtein and Ofra Golani and Lee, \{Se Jin\} and Konstantin Feinberg and Natasha Sukhanov and Greenspan, \{Daniel S.\} and Keiichiro Susuki and Rasband, \{Matthew N.\} and Elior Peles",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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doi = "10.1016/j.neuron.2020.03.001",

language = "English (US)",

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AU - Eshed-Eisenbach, Yael

AU - Devaux, Jerome

AU - Vainshtein, Anna

AU - Golani, Ofra

AU - Lee, Se Jin

AU - Feinberg, Konstantin

AU - Sukhanov, Natasha

AU - Greenspan, Daniel S.

AU - Susuki, Keiichiro

AU - Rasband, Matthew N.

AU - Peles, Elior

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KW - Gliomedin

KW - Myelin

KW - Neurofascin

KW - Node of Ranvier

KW - PNS development

KW - Schwann cells

KW - Sodium channels

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