Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896

Richard J. Lamb; Roland R. Griffiths

doi:10.1016/0376-8716(84)90013-9

Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896

Richard J. Lamb, Roland R. Griffiths

School of Medicine

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

In order to assess the ability of lorazepam (20 mg/kg/day) and CGS 9896 (100 mg/kg/day) to produce physical-dependence in baboons, the occurrence of Ro 15-1788 precipitated withdrawal signs and spontaneous withdrawal signs were determined. Lorazepam-treated baboons displayed precipitated withdrawal signs following the administration of Ro 15-1788 (5 mg/ kg), and displayed mild to moderate spontaneous withdrawal signs following termination of drug treatment. CGS 9896-treated baboons did not display Ro 15-1788 precipitated withdrawal signs and displayed either no or only mild spontaneous withdrawal signs.

Original language	English (US)
Pages (from-to)	11-17
Number of pages	7
Journal	Drug and alcohol dependence
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/0376-8716(84)90013-9
State	Published - Sep 1984

Keywords

Baboon
Benzodiazepine
CGS 9896
Flumazepil
Lorazepam
Physical dependence
Ro 15-1788

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/0376-8716(84)90013-9

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title = "Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896",

abstract = "In order to assess the ability of lorazepam (20 mg/kg/day) and CGS 9896 (100 mg/kg/day) to produce physical-dependence in baboons, the occurrence of Ro 15-1788 precipitated withdrawal signs and spontaneous withdrawal signs were determined. Lorazepam-treated baboons displayed precipitated withdrawal signs following the administration of Ro 15-1788 (5 mg/ kg), and displayed mild to moderate spontaneous withdrawal signs following termination of drug treatment. CGS 9896-treated baboons did not display Ro 15-1788 precipitated withdrawal signs and displayed either no or only mild spontaneous withdrawal signs.",

keywords = "Baboon, Benzodiazepine, CGS 9896, Flumazepil, Lorazepam, Physical dependence, Ro 15-1788",

author = "Lamb, {Richard J.} and Griffiths, {Roland R.}",

note = "Funding Information: *This research was supported by National Institute on Drug Abuse grant DA 01147 and Contract 271-80-3718. **Recipient of the National Institute on Drug Abuse National Research Service Award DA 05237. ***To whom reprint requests should be sent. Abbreviation: FR, fixed ratio.",

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AU - Griffiths, Roland R.

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PY - 1984/9

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N2 - In order to assess the ability of lorazepam (20 mg/kg/day) and CGS 9896 (100 mg/kg/day) to produce physical-dependence in baboons, the occurrence of Ro 15-1788 precipitated withdrawal signs and spontaneous withdrawal signs were determined. Lorazepam-treated baboons displayed precipitated withdrawal signs following the administration of Ro 15-1788 (5 mg/ kg), and displayed mild to moderate spontaneous withdrawal signs following termination of drug treatment. CGS 9896-treated baboons did not display Ro 15-1788 precipitated withdrawal signs and displayed either no or only mild spontaneous withdrawal signs.

AB - In order to assess the ability of lorazepam (20 mg/kg/day) and CGS 9896 (100 mg/kg/day) to produce physical-dependence in baboons, the occurrence of Ro 15-1788 precipitated withdrawal signs and spontaneous withdrawal signs were determined. Lorazepam-treated baboons displayed precipitated withdrawal signs following the administration of Ro 15-1788 (5 mg/ kg), and displayed mild to moderate spontaneous withdrawal signs following termination of drug treatment. CGS 9896-treated baboons did not display Ro 15-1788 precipitated withdrawal signs and displayed either no or only mild spontaneous withdrawal signs.

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KW - Ro 15-1788

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Precipitated and spontaneous withdrawal in baboons after chronic dosing with lorazepam and CGS 9896

Abstract

Keywords

ASJC Scopus subject areas

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