Precancerous lesions of the pancreas

Giuseppe Zamboni, Kenichi Hirabayashi, Paola Castelli, Anne Marie Lennon

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Pancreatic cancer has a very poor prognosis, with a five year survival of only 5%. New studies have shown that it takes over 11 years for cells to develop invasive capability. This provides an opportunity to intervene if precursor lesions can be detected. This paper reviews the molecular, pathological, clinical findings and management of pancreatic intraepithelial neoplasia (PanIN), intraductal pancreatic mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), three precursor lesions which can give rise to invasive carcinoma of the pancreas.

Original languageEnglish (US)
Pages (from-to)299-322
Number of pages24
JournalBest Practice and Research: Clinical Gastroenterology
Issue number2
StatePublished - Apr 2013


  • Pancreas
  • Pancreatic cancer
  • Pancreatic neoplasms
  • Pathology
  • Precancerous lesions

ASJC Scopus subject areas

  • Gastroenterology


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