Pre-menopausal and post-menopausal depressed women

Alec Roy, Markku Linnoila, David C. Jimerson, Philip Gold, David Pickar

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In a consecutive series of 28 depressed women, pre-menopausal (n = 13) and post-menopausal (n = 15) patients were compared. Post-menopausal women had significantly higher levels of plasma norepinephrine, plasma 3-methoxy-4-hydroxyphenylglycol, post-dexamethasone plasma cortisol, cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol and corticotropin-releasing hormone. However, when biologic measures were adjusted for age by analyses of covariance there were no significant differences. Pre-menopausal women had had significantly more life events before the onset of depression than post-menopausal women. The implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalAustralasian Psychiatry
Issue number4
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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