Practical applications of therapy with a glucagon-like peptide-1 receptor agonist

Mansur E. Shomali

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Patients such as ML represent a common challenge in the primary care management of patients with T2DM. After some response to initial therapy with lifestyle management and metformin, the A1C goal of <7.0% after 2 to 3 months was not achieved, necessitating the initiation of combination therapy. The 4 groups of medications recommended by the ADA/EASD panel as the preferred therapies are basal insulin, the sulfonylureas, the TZD pioglitazone, and GLP-1 receptor agonists. In addition to considering efficacy, safety, cost, and other medication-related factors, the treatment plan must take into account the patient's individual needs, concerns, and capabilities. These additional considerations help to foster increased patient self-management and greater treatment adherence. To achieve these objectives, comprehensive patient education is essential. The unique mechanism of action of the GLP-1 receptor agonist class of medications makes these agents a desirable choice as add-on therapy to metformin.

Original languageEnglish (US)
Pages (from-to)S35-S43
JournalJournal of Family Practice
Issue number9 SUPPL.
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Family Practice


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