PPAR alpha regulation of the immune response and autoimmune encephalomyelitis

Yuhong Yang, Anne R. Gocke, Amy Lovett-Racke, Paul D. Drew, Michael K. Racke

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


PPARs are members of the steroid hormone nuclear receptor superfamily and play an important role in the regulation of lipid metabolism, energy balance, artherosclerosis and glucose control. Recent studies suggest that they play an important role in regulating inflammation. This review will focus on PPAR-α regulation of the immune response. We describe how PPAR-α regulates differentiation of T cells by transactivation and/or interaction with other transcription factors. Moreover, PPAR-α agonists have been shown to ameliorate experimental autoimmune encephalomyelitis (EAE) in mice, suggesting that they could provide a therapy for human autoimmune diseases such as multiple sclerosis.

Original languageEnglish (US)
Article number546753
JournalPPAR Research
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology (medical)


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