TY - JOUR
T1 - PPARγ in immunity and inflammation
T2 - cell types and diseases
AU - Széles, Lajos
AU - Töröcsik, Dániel
AU - Nagy, László
N1 - Funding Information:
The work in the authors' laboratories is supported by grants from the National Office for Research and Technology (NKFP 2004 OM-00427 and RET-06/2004 to LN).
PY - 2007/8
Y1 - 2007/8
N2 - The lipid activated transcription factor, PPARγ appears to have multiple functions in the immune system. There are several cell types expressing the receptor, most prominently antigen presenting cells, such as macrophages and dendritic cells. The receptor's activation leads to primary transcriptional activation of many, mostly lipid metabolism-related genes. However, gene regulation also occurs on immunity and inflammation-related genes. Key questions are: in what way lipid metabolism and immune regulation are connected and how activation and/or repression of gene expression may modulate inflammatory and anti-inflammatory responses and in what way can these be utilized in therapy. Here we provide a cell type and disease centric review on the role of this lipid activated transcription factor in the various cells of the immune system it is expressed in, and in some major inflammatory diseases such as atherosclerosis, inflammatory bowel disease and rheumatoid arthritis.
AB - The lipid activated transcription factor, PPARγ appears to have multiple functions in the immune system. There are several cell types expressing the receptor, most prominently antigen presenting cells, such as macrophages and dendritic cells. The receptor's activation leads to primary transcriptional activation of many, mostly lipid metabolism-related genes. However, gene regulation also occurs on immunity and inflammation-related genes. Key questions are: in what way lipid metabolism and immune regulation are connected and how activation and/or repression of gene expression may modulate inflammatory and anti-inflammatory responses and in what way can these be utilized in therapy. Here we provide a cell type and disease centric review on the role of this lipid activated transcription factor in the various cells of the immune system it is expressed in, and in some major inflammatory diseases such as atherosclerosis, inflammatory bowel disease and rheumatoid arthritis.
KW - Atherosclerosis
KW - Chronic inflammation
KW - Dendritic cell
KW - Inflammation
KW - Inflammatory bowel disease
KW - Macrophage
KW - Peroxisome Proliferator-Activated Receptor gamma
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U2 - 10.1016/j.bbalip.2007.02.005
DO - 10.1016/j.bbalip.2007.02.005
M3 - Review article
C2 - 17418635
AN - SCOPUS:34547627893
SN - 1388-1981
VL - 1771
SP - 1014
EP - 1030
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 8
ER -