Potential involvement of the interleukin-18 pathway in schizophrenia

Yong Xu; Weihua Yue; Yin Yao Shugart; Jianmin Yuan; Guoqiang Wang; Harold Z. Wang; Benjamin Lehrman; Fuquan Zhang; Dai Zhang

doi:10.1016/j.jpsychires.2015.12.013

Potential involvement of the interleukin-18 pathway in schizophrenia

Yong Xu, Weihua Yue, Yin Yao Shugart, Jianmin Yuan, Guoqiang Wang, Harold Z. Wang, Benjamin Lehrman, Fuquan Zhang, Dai Zhang

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective: Accumulating evidence implicates inflammatory cytokines in the development of psychiatric disorders, including schizophrenia (SZ). IL-18 is one of cytokines that plays a crucial role in immune response and neurodevelopment. We aimed to investigate potential genetic alterations of the cytokine system underpinning SZ. Methods: We tested the association of genetic variants within the cytokine-cytokine receptor interaction (CCRI) pathway with SZ, using GWAS-derived data involving 768 adult SZ patients and 1348 controls, and replicated the association of IL18R1 rs1035130 with SZ in an independent sample of 1957 adult patients and 1509 controls. We compared expression levels of IL18, IL18R1 and IL18RAP in peripheral blood of a cohort of adolescent participants (

Original language	English (US)
Pages (from-to)	10-16
Number of pages	7
Journal	Journal of Psychiatric Research
Volume	74
DOIs	https://doi.org/10.1016/j.jpsychires.2015.12.013
State	Published - Mar 1 2016
Externally published	Yes

Keywords

IL18
IL18R1
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Arts and Humanities (miscellaneous)

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10.1016/j.jpsychires.2015.12.013

Cite this

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title = "Potential involvement of the interleukin-18 pathway in schizophrenia",

abstract = "Objective: Accumulating evidence implicates inflammatory cytokines in the development of psychiatric disorders, including schizophrenia (SZ). IL-18 is one of cytokines that plays a crucial role in immune response and neurodevelopment. We aimed to investigate potential genetic alterations of the cytokine system underpinning SZ. Methods: We tested the association of genetic variants within the cytokine-cytokine receptor interaction (CCRI) pathway with SZ, using GWAS-derived data involving 768 adult SZ patients and 1348 controls, and replicated the association of IL18R1 rs1035130 with SZ in an independent sample of 1957 adult patients and 1509 controls. We compared expression levels of IL18, IL18R1 and IL18RAP in peripheral blood of a cohort of adolescent participants (",

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T1 - Potential involvement of the interleukin-18 pathway in schizophrenia

AU - Xu, Yong

AU - Yue, Weihua

AU - Shugart, Yin Yao

AU - Yuan, Jianmin

AU - Wang, Guoqiang

AU - Wang, Harold Z.

AU - Lehrman, Benjamin

AU - Zhang, Fuquan

AU - Zhang, Dai

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective: Accumulating evidence implicates inflammatory cytokines in the development of psychiatric disorders, including schizophrenia (SZ). IL-18 is one of cytokines that plays a crucial role in immune response and neurodevelopment. We aimed to investigate potential genetic alterations of the cytokine system underpinning SZ. Methods: We tested the association of genetic variants within the cytokine-cytokine receptor interaction (CCRI) pathway with SZ, using GWAS-derived data involving 768 adult SZ patients and 1348 controls, and replicated the association of IL18R1 rs1035130 with SZ in an independent sample of 1957 adult patients and 1509 controls. We compared expression levels of IL18, IL18R1 and IL18RAP in peripheral blood of a cohort of adolescent participants (

AB - Objective: Accumulating evidence implicates inflammatory cytokines in the development of psychiatric disorders, including schizophrenia (SZ). IL-18 is one of cytokines that plays a crucial role in immune response and neurodevelopment. We aimed to investigate potential genetic alterations of the cytokine system underpinning SZ. Methods: We tested the association of genetic variants within the cytokine-cytokine receptor interaction (CCRI) pathway with SZ, using GWAS-derived data involving 768 adult SZ patients and 1348 controls, and replicated the association of IL18R1 rs1035130 with SZ in an independent sample of 1957 adult patients and 1509 controls. We compared expression levels of IL18, IL18R1 and IL18RAP in peripheral blood of a cohort of adolescent participants (

KW - IL18

KW - IL18R1

KW - Schizophrenia

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JF - Journal of Psychiatric Research

ER -

Potential involvement of the interleukin-18 pathway in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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