Potential involvement of the interleukin-18 pathway in schizophrenia

Yong Xu, Weihua Yue, Yin Yao Shugart, Jianmin Yuan, Guoqiang Wang, Harold Z. Wang, Benjamin Lehrman, Fuquan Zhang, Dai Zhang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: Accumulating evidence implicates inflammatory cytokines in the development of psychiatric disorders, including schizophrenia (SZ). IL-18 is one of cytokines that plays a crucial role in immune response and neurodevelopment. We aimed to investigate potential genetic alterations of the cytokine system underpinning SZ. Methods: We tested the association of genetic variants within the cytokine-cytokine receptor interaction (CCRI) pathway with SZ, using GWAS-derived data involving 768 adult SZ patients and 1348 controls, and replicated the association of IL18R1 rs1035130 with SZ in an independent sample of 1957 adult patients and 1509 controls. We compared expression levels of IL18, IL18R1 and IL18RAP in peripheral blood of a cohort of adolescent participants (

Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalJournal of Psychiatric Research
StatePublished - Mar 1 2016
Externally publishedYes


  • IL18
  • IL18R1
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Arts and Humanities (miscellaneous)


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