Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes

Michael Gordon Silverman; Michael J. Blaha; Matthew J. Budoff; Juan J. Rivera; Paolo Raggi; Leslee J. Shaw; Daniel Berman; Tracy Callister; John A. Rumberger; Jamal S. Rana; Roger S. Blumenthal; Khurram Nasir

doi:10.2337/dc11-1773

Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes

Michael Gordon Silverman, Michael J. Blaha, Matthew J. Budoff, Juan J. Rivera, Paolo Raggi, Leslee J. Shaw, Daniel Berman, Tracy Callister, John A. Rumberger, Jamal S. Rana, Roger S. Blumenthal, Khurram Nasir

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

OBJECTIVE - It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain. RESEARCH DESIGN AND METHODS - Of 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for amean of 5.6 6 2.6 years for the end point of all-cause mortality. RESULTS - There were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit. CONCLUSIONS - CAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention.

Original language	English (US)
Pages (from-to)	624-626
Number of pages	3
Journal	Diabetes care
Volume	35
Issue number	3
DOIs	https://doi.org/10.2337/dc11-1773
State	Published - Mar 2012

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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Silverman, M. G., Blaha, M. J., Budoff, M. J., Rivera, J. J., Raggi, P., Shaw, L. J., Berman, D., Callister, T., Rumberger, J. A., Rana, J. S., Blumenthal, R. S., & Nasir, K. (2012). Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes. Diabetes care, 35(3), 624-626. https://doi.org/10.2337/dc11-1773

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title = "Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes",

abstract = "OBJECTIVE - It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain. RESEARCH DESIGN AND METHODS - Of 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for amean of 5.6 6 2.6 years for the end point of all-cause mortality. RESULTS - There were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit. CONCLUSIONS - CAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention.",

author = "Silverman, {Michael Gordon} and Blaha, {Michael J.} and Budoff, {Matthew J.} and Rivera, {Juan J.} and Paolo Raggi and Shaw, {Leslee J.} and Daniel Berman and Tracy Callister and Rumberger, {John A.} and Rana, {Jamal S.} and Blumenthal, {Roger S.} and Khurram Nasir",

year = "2012",

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doi = "10.2337/dc11-1773",

language = "English (US)",

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pages = "624--626",

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T1 - Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes

AU - Silverman, Michael Gordon

AU - Blaha, Michael J.

AU - Budoff, Matthew J.

AU - Rivera, Juan J.

AU - Raggi, Paolo

AU - Shaw, Leslee J.

AU - Berman, Daniel

AU - Callister, Tracy

AU - Rumberger, John A.

AU - Rana, Jamal S.

AU - Blumenthal, Roger S.

AU - Nasir, Khurram

PY - 2012/3

Y1 - 2012/3

N2 - OBJECTIVE - It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain. RESEARCH DESIGN AND METHODS - Of 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for amean of 5.6 6 2.6 years for the end point of all-cause mortality. RESULTS - There were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit. CONCLUSIONS - CAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention.

AB - OBJECTIVE - It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain. RESEARCH DESIGN AND METHODS - Of 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for amean of 5.6 6 2.6 years for the end point of all-cause mortality. RESULTS - There were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit. CONCLUSIONS - CAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention.

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Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes

Abstract

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