Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review

Aliyu Muhammad; Gilead Ebiegberi Forcados; Babangida Sanusi Katsayal; Rabiatu Suleiman Bako; Suleiman Aminu; Idris Zubairu Sadiq; Murtala Bello Abubakar; Abdurrahman Pharmacy Yusuf; Ibrahim Malami; Mohammed Faruk; Sani Ibrahim; Peter Abur Pase; Saad Ahmed; Ibrahim Babangida Abubakar; Murtala Abubakar; Clayton Yates

doi:10.2217/epi-2022-0033

Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review

Aliyu Muhammad
, Gilead Ebiegberi Forcados
, Babangida Sanusi Katsayal
, Rabiatu Suleiman Bako
, Suleiman Aminu
, Idris Zubairu Sadiq
, Murtala Bello Abubakar
, Abdurrahman Pharmacy Yusuf
, Ibrahim Malami
, Mohammed Faruk
, Sani Ibrahim
, Peter Abur Pase
, Saad Ahmed
, Ibrahim Babangida Abubakar
, Murtala Abubakar
, Clayton Yates

Research output: Contribution to journal › Review article › peer-review

Abstract

Current research on triple-negative breast cancer (TNBC) has resulted in delineation into the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as DNA methylation, histone posttranslational modifications and associated changes in chromatin architecture have been implicated in breast cancer pathogenesis. Herein, the authors highlight genes with observed epigenetic modifications that are associated with more aggressive TNBC/QNBC pathogenesis and possible interventions. Advanced literature searches were done on PubMed/MEDLINE, Scopus and Google Scholar. The results suggest that nine epigenetically altered genes/differentially expressed proteins in addition to the downregulated androgen receptor are associated with TNBC aggressiveness and could be implicated in the TNBC to QNBC transition. Thus, restoring the normal expression of these genes via epigenetic reprogramming could be therapeutically beneficial to TNBC and QNBC patients.

Original language	English (US)
Pages (from-to)	711-726
Number of pages	16
Journal	Epigenomics
Volume	14
Issue number	11
DOIs	https://doi.org/10.2217/epi-2022-0033
State	Published - Jun 2022
Externally published	Yes

Keywords

epigenetic modifications
genes
quadruple-negative breast cancer
therapeutic targets
triple-negative breast cancer

ASJC Scopus subject areas

Genetics
Cancer Research

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10.2217/epi-2022-0033

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Muhammad, A., Forcados, G. E., Katsayal, B. S., Bako, R. S., Aminu, S., Sadiq, I. Z., Abubakar, M. B., Yusuf, A. P., Malami, I., Faruk, M., Ibrahim, S., Pase, P. A., Ahmed, S., Abubakar, I. B., Abubakar, M., & Yates, C. (2022). Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review. Epigenomics, 14(11), 711-726. https://doi.org/10.2217/epi-2022-0033

Muhammad, A, Forcados, GE, Katsayal, BS, Bako, RS, Aminu, S, Sadiq, IZ, Abubakar, MB, Yusuf, AP, Malami, I, Faruk, M, Ibrahim, S, Pase, PA, Ahmed, S, Abubakar, IB, Abubakar, M & Yates, C 2022, 'Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review', Epigenomics, vol. 14, no. 11, pp. 711-726. https://doi.org/10.2217/epi-2022-0033

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title = "Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review",

abstract = "Current research on triple-negative breast cancer (TNBC) has resulted in delineation into the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as DNA methylation, histone posttranslational modifications and associated changes in chromatin architecture have been implicated in breast cancer pathogenesis. Herein, the authors highlight genes with observed epigenetic modifications that are associated with more aggressive TNBC/QNBC pathogenesis and possible interventions. Advanced literature searches were done on PubMed/MEDLINE, Scopus and Google Scholar. The results suggest that nine epigenetically altered genes/differentially expressed proteins in addition to the downregulated androgen receptor are associated with TNBC aggressiveness and could be implicated in the TNBC to QNBC transition. Thus, restoring the normal expression of these genes via epigenetic reprogramming could be therapeutically beneficial to TNBC and QNBC patients.",

keywords = "epigenetic modifications, genes, quadruple-negative breast cancer, therapeutic targets, triple-negative breast cancer",

author = "Aliyu Muhammad and Forcados, \{Gilead Ebiegberi\} and Katsayal, \{Babangida Sanusi\} and Bako, \{Rabiatu Suleiman\} and Suleiman Aminu and Sadiq, \{Idris Zubairu\} and Abubakar, \{Murtala Bello\} and Yusuf, \{Abdurrahman Pharmacy\} and Ibrahim Malami and Mohammed Faruk and Sani Ibrahim and Pase, \{Peter Abur\} and Saad Ahmed and Abubakar, \{Ibrahim Babangida\} and Murtala Abubakar and Clayton Yates",

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year = "2022",

month = jun,

doi = "10.2217/epi-2022-0033",

language = "English (US)",

volume = "14",

pages = "711--726",

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TY - JOUR

T1 - Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition

T2 - a review

AU - Muhammad, Aliyu

AU - Forcados, Gilead Ebiegberi

AU - Katsayal, Babangida Sanusi

AU - Bako, Rabiatu Suleiman

AU - Aminu, Suleiman

AU - Sadiq, Idris Zubairu

AU - Abubakar, Murtala Bello

AU - Yusuf, Abdurrahman Pharmacy

AU - Malami, Ibrahim

AU - Faruk, Mohammed

AU - Ibrahim, Sani

AU - Pase, Peter Abur

AU - Ahmed, Saad

AU - Abubakar, Ibrahim Babangida

AU - Abubakar, Murtala

AU - Yates, Clayton

PY - 2022/6

Y1 - 2022/6

N2 - Current research on triple-negative breast cancer (TNBC) has resulted in delineation into the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as DNA methylation, histone posttranslational modifications and associated changes in chromatin architecture have been implicated in breast cancer pathogenesis. Herein, the authors highlight genes with observed epigenetic modifications that are associated with more aggressive TNBC/QNBC pathogenesis and possible interventions. Advanced literature searches were done on PubMed/MEDLINE, Scopus and Google Scholar. The results suggest that nine epigenetically altered genes/differentially expressed proteins in addition to the downregulated androgen receptor are associated with TNBC aggressiveness and could be implicated in the TNBC to QNBC transition. Thus, restoring the normal expression of these genes via epigenetic reprogramming could be therapeutically beneficial to TNBC and QNBC patients.

AB - Current research on triple-negative breast cancer (TNBC) has resulted in delineation into the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as DNA methylation, histone posttranslational modifications and associated changes in chromatin architecture have been implicated in breast cancer pathogenesis. Herein, the authors highlight genes with observed epigenetic modifications that are associated with more aggressive TNBC/QNBC pathogenesis and possible interventions. Advanced literature searches were done on PubMed/MEDLINE, Scopus and Google Scholar. The results suggest that nine epigenetically altered genes/differentially expressed proteins in addition to the downregulated androgen receptor are associated with TNBC aggressiveness and could be implicated in the TNBC to QNBC transition. Thus, restoring the normal expression of these genes via epigenetic reprogramming could be therapeutically beneficial to TNBC and QNBC patients.

KW - epigenetic modifications

KW - genes

KW - quadruple-negative breast cancer

KW - therapeutic targets

KW - triple-negative breast cancer

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UR - https://www.scopus.com/pages/publications/85131771176#tab=citedBy

U2 - 10.2217/epi-2022-0033

DO - 10.2217/epi-2022-0033

M3 - Review article

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AN - SCOPUS:85131771176

SN - 1750-1911

VL - 14

SP - 711

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JO - Epigenomics

JF - Epigenomics

IS - 11

ER -

Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review

Abstract

Keywords

ASJC Scopus subject areas

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