@article{1acf2d8980ef4ee591a68a9900b110f5,
title = "Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection",
abstract = "An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and reduced the M. abscessus sputum load tenfold within one month. However, after two months, M. abscessus counts increased as the patient mounted a robust IgM- and IgG-mediated neutralizing antibody response to the phages, which was associated with limited therapeutic efficacy.",
author = "Dedrick, {Rebekah M.} and Freeman, {Krista G.} and Nguyen, {Jan A.} and Asli Bahadirli-Talbott and Smith, {Bailey E.} and Wu, {Andrew E.} and Ong, {Aaron S.} and Lin, {Cheng Ting} and Ruppel, {Lisa C.} and Parrish, {Nicole M.} and Hatfull, {Graham F.} and Cohen, {Keira A.}",
note = "Funding Information: We thank D. Jacobs-Sera and H. G. Aull for the phage cocktail preparation, R. Garlena and D. Russell at the University of Pittsburgh for DNA sequencing and analysis and M. Ramsay, C. Lippincott, J. Zenilman, K. Dooley and E. Ignatius at Johns Hopkins University School of Medicine for their clinical discussions regarding the care of this patient. This work was funded by a Cystic Fibrosis Foundation grant no. HATFUL19GO, a National Institutes of Health (NIH) grant no. GM131729, a Howard Hughes Medical Institute grant no. GT12053 and by the Fowler Fund for Phage Research to G.F.H. as well as grants from the National Heart, Lung, and Blood Institute/NIH (no. K08 HL139994) and the Burroughs Wellcome Fund Career Award for Medical Scientists to K.A.C. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. We thank R. Schooley, E. Rubin and B. Bishai for comments on the manuscript. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2021",
month = aug,
doi = "10.1038/s41591-021-01403-9",
language = "English (US)",
volume = "27",
pages = "1357--1361",
journal = "Nature medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "8",
}