Abstract
Atherosclerosis is the primary cause of heart disease and stroke, as such it the underlying cause of about half of all deaths in the industrialized world. To gain a more comprehensive mechanistic understanding of atherosclerosis, one approach is the careful analysis of proteins, the crosstalk and selectivity of different post-translational modifications (PTMs). Analysis of PTMs presents formidable challenges but the identification of the types of PTMs, the modified proteins and the exact altered amino acids is an essential first step. There are currently several different experimental strategies that can be employed to explore PTM proteomes. This review will cover the PTMs phosphorylation, acetylation, and methylation as important regulators of atherosclerosis and will discuss current methods available for their detection, enrichment and quantification. These endeavors will advance our understanding of the molecular pathways and potentially lead to the identification of diagnostic and prognostic biomarkers as well as therapeutic targets.
| Original language | English (US) |
|---|---|
| Title of host publication | Atherosclerosis |
| Subtitle of host publication | Risks, Mechanisms, and Therapies |
| Publisher | Wiley-Blackwell |
| Pages | 437-451 |
| Number of pages | 15 |
| ISBN (Electronic) | 9781118828533 |
| ISBN (Print) | 9781118285916 |
| DOIs | |
| State | Published - Mar 27 2015 |
Keywords
- Acetylation
- Atherosclerosis
- Methylation
- Posttranslational modifications (PTMs)
- Protein phosphorylation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)