Post‐sepsis prophylaxis in cancer patients

Walter T. Hughes, Gayle Patterson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


One hundred children with cancer and bacterial sepsis were observed for one month after completion of antibiotic treatment for subsequent episodes of infection. After satisfactory clinical and bacteriological responses were achieved and antibiotic therapy terminated, 38 of the patients were maintained on trimethoprim‐sulfamethoxazole (TMP‐SMZ) and 62 did not receive the drug combination. Of the 26 neutropenic patients not receiving TMP‐SMZ 23 (88%) had episodes of infection, whereas 4 (36%) of the 11 given the drug had recurrent of re‐infection episodes (P = <0.001). A difference of similar significance was observed in the non‐neutropenic patients. Infections in children in relapse of their malignancy were twice as frequent in those not receiving the drug as in those who received it (P = <0.02, >0.01). Of the 19 patients who died during the month of observation, none had received TMP‐SMZ. This study shows that the administration of TMP‐SMZ after bacterial sepsis reduces the number of infectious episodes in neutropenic and non‐neutropenic patients, with the exception of the non‐neutropenic patient in remission. Cancer 53:137‐141, 1984.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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