Postpartum depression biomarkers predict exacerbation of OCD symptoms during pregnancy

Zachary A. Kaminsky; Lauren M. Osborne; Valeria Guglielmi; Ilenna Jones; Winston Grenier; Karen Clark; Evelyn Ross; Samantha Meilman; Paul Nestadt; Jennifer L. Payne; Jack Samuels; Gerald Nestadt

doi:10.1016/j.psychres.2020.113332

Postpartum depression biomarkers predict exacerbation of OCD symptoms during pregnancy

Zachary A. Kaminsky, Lauren M. Osborne, Valeria Guglielmi, Ilenna Jones, Winston Grenier, Karen Clark, Evelyn Ross, Samantha Meilman, Paul Nestadt, Jennifer L. Payne, Jack Samuels, Gerald Nestadt

School of Medicine

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Article number	113332
Journal	Psychiatry research
Volume	293
DOIs	https://doi.org/10.1016/j.psychres.2020.113332
State	Published - Nov 2020

Keywords

HP1BP3
Obsessive compulsive disorder
TTC9B
biomarkers
epigenetics
postpartum depression
pregnancy

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2020.113332

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@article{9d58a5d48a704652880d75bd56074f0d,

title = "Postpartum depression biomarkers predict exacerbation of OCD symptoms during pregnancy",

keywords = "HP1BP3, Obsessive compulsive disorder, TTC9B, biomarkers, epigenetics, postpartum depression, pregnancy",

author = "Kaminsky, {Zachary A.} and Osborne, {Lauren M.} and Valeria Guglielmi and Ilenna Jones and Winston Grenier and Karen Clark and Evelyn Ross and Samantha Meilman and Paul Nestadt and Payne, {Jennifer L.} and Jack Samuels and Gerald Nestadt",

note = "Funding Information: Z.K. and J.P. are listed as investors on a patent to use the above biomarkers to predict postpartum depression. Z.K. is the founder of and holds equity in METHYX LLC. He also serves as the company's Managing Member. METHYX LLC intends to license technology used in the study that is described in this publication. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies. J.P. received legal consulting fees from Astra Zeneca, Eli Lilly, Johnson & Johnson, and Abbott Pharmaceuticals and received research support from the NIMH, the Stanley Medical Research Foundation, and SAGE Therapeutics. All other authors declare that they have no competing interests.We would like to thank The Solomon R. & Rebecca D. Baker Foundation, DIFD, and the Mach-Gaensslen Foundation for their generous support of this research. This work was supported by a 2010 NARSAD Young Investigator Award, R01MH104262, K23 MH074799-01A2, R01-MH50214, R01-MH071507, NIH/NCRR/OPD-GCRC RR00052, and the James E. Marshall OCD Foundation. The Johns Hopkins University IRB approved this research and all subjects gave consent for the study. Prospective human subjects{\textquoteright} research for the Johns Hopkins Prospective PPD Cohort was conducted under IRB protocol # 00008149. Prospective human subjects{\textquoteright} research for the Johns Hopkins BRAINS Neuroimaging Cohort was conducted under Johns Hopkins IRB protocols # 00038271 and 00027369. Human subjects{\textquoteright} research for the OCD cohort was conducted under Johns Hopkins IRB protocol # NA_00039786/CR00013867. All protocols conform to the Declaration of Helsinki. Funding Information: We would like to thank The Solomon R. & Rebecca D. Baker Foundation, DIFD, and the Mach-Gaensslen Foundation for their generous support of this research. This work was supported by a 2010 NARSAD Young Investigator Award, R01MH104262 , K23 MH074799-01A2 , R01-MH50214 , R01-MH071507 , NIH / NCRR /OPD-GCRC RR00052, and the James E. Marshall OCD Foundation . The Johns Hopkins University IRB approved this research and all subjects gave consent for the study. Prospective human subjects{\textquoteright} research for the Johns Hopkins Prospective PPD Cohort was conducted under IRB protocol # 00008149. Prospective human subjects{\textquoteright} research for the Johns Hopkins BRAINS Neuroimaging Cohort was conducted under Johns Hopkins IRB protocols # 00038271 and 00027369. Human subjects{\textquoteright} research for the OCD cohort was conducted under Johns Hopkins IRB protocol # NA_00039786/CR00013867. All protocols conform to the Declaration of Helsinki. ",

year = "2020",

month = nov,

doi = "10.1016/j.psychres.2020.113332",

language = "English (US)",

volume = "293",

journal = "Psychiatry research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Postpartum depression biomarkers predict exacerbation of OCD symptoms during pregnancy

AU - Kaminsky, Zachary A.

AU - Osborne, Lauren M.

AU - Guglielmi, Valeria

AU - Jones, Ilenna

AU - Grenier, Winston

AU - Clark, Karen

AU - Ross, Evelyn

AU - Meilman, Samantha

AU - Nestadt, Paul

AU - Payne, Jennifer L.

AU - Samuels, Jack

AU - Nestadt, Gerald

N1 - Funding Information: Z.K. and J.P. are listed as investors on a patent to use the above biomarkers to predict postpartum depression. Z.K. is the founder of and holds equity in METHYX LLC. He also serves as the company's Managing Member. METHYX LLC intends to license technology used in the study that is described in this publication. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies. J.P. received legal consulting fees from Astra Zeneca, Eli Lilly, Johnson & Johnson, and Abbott Pharmaceuticals and received research support from the NIMH, the Stanley Medical Research Foundation, and SAGE Therapeutics. All other authors declare that they have no competing interests.We would like to thank The Solomon R. & Rebecca D. Baker Foundation, DIFD, and the Mach-Gaensslen Foundation for their generous support of this research. This work was supported by a 2010 NARSAD Young Investigator Award, R01MH104262, K23 MH074799-01A2, R01-MH50214, R01-MH071507, NIH/NCRR/OPD-GCRC RR00052, and the James E. Marshall OCD Foundation. The Johns Hopkins University IRB approved this research and all subjects gave consent for the study. Prospective human subjects’ research for the Johns Hopkins Prospective PPD Cohort was conducted under IRB protocol # 00008149. Prospective human subjects’ research for the Johns Hopkins BRAINS Neuroimaging Cohort was conducted under Johns Hopkins IRB protocols # 00038271 and 00027369. Human subjects’ research for the OCD cohort was conducted under Johns Hopkins IRB protocol # NA_00039786/CR00013867. All protocols conform to the Declaration of Helsinki. Funding Information: We would like to thank The Solomon R. & Rebecca D. Baker Foundation, DIFD, and the Mach-Gaensslen Foundation for their generous support of this research. This work was supported by a 2010 NARSAD Young Investigator Award, R01MH104262 , K23 MH074799-01A2 , R01-MH50214 , R01-MH071507 , NIH / NCRR /OPD-GCRC RR00052, and the James E. Marshall OCD Foundation . The Johns Hopkins University IRB approved this research and all subjects gave consent for the study. Prospective human subjects’ research for the Johns Hopkins Prospective PPD Cohort was conducted under IRB protocol # 00008149. Prospective human subjects’ research for the Johns Hopkins BRAINS Neuroimaging Cohort was conducted under Johns Hopkins IRB protocols # 00038271 and 00027369. Human subjects’ research for the OCD cohort was conducted under Johns Hopkins IRB protocol # NA_00039786/CR00013867. All protocols conform to the Declaration of Helsinki.

PY - 2020/11

Y1 - 2020/11

KW - HP1BP3

KW - Obsessive compulsive disorder

KW - TTC9B

KW - biomarkers

KW - epigenetics

KW - postpartum depression

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85089200880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85089200880&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2020.113332

DO - 10.1016/j.psychres.2020.113332

M3 - Letter

C2 - 32781363

AN - SCOPUS:85089200880

SN - 0165-1781

VL - 293

JO - Psychiatry research

JF - Psychiatry research

M1 - 113332

ER -

Postpartum depression biomarkers predict exacerbation of OCD symptoms during pregnancy

Keywords

ASJC Scopus subject areas

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