Postoperative sinonasal morbidity in sellar reconstruction: mucosal autograft versus acellular dermal allograft

Christopher R. Roxbury, J. Trent Magruder, Murugappan Ramanathan, Michael Lim, Gary L. Gallia, Masaru Ishii, Douglas D. Reh

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Sellar pathology is increasingly addressed using the expanded endonasal approach (EEA). Although avascular graft reconstruction is an acceptable means to prevent cerebrospinal fluid leak, there are few data regarding sinonasal morbidity in these patients. In this study we compare rates of persistent postoperative crusting (PPC) and rhinosinusitis in patients undergoing sellar reconstruction with mucosal autografting and acellular dermal allografting (ADA). Methods: Patients undergoing the EEA between 2008 and 2014 were categorized into 2 subgroups: mucosal reconstruction and ADA reconstruction. Univariate analyses were performed to compare differences in PPC and rhinosinusitis in these groups and to identify risk factors for sinonasal morbidity. Multivariate propensity matching analysis was performed to match ADA and mucosa reconstruction groups with respect to age, race, gender, smoking status, diabetes status, tumor type, tumor size, and revision vs primary surgery. Results: A total of 149 patients were identified. There were 105 patients reconstructed with autologous mucosa (70.5%) and 44 reconstructed with ADA (29.5%). Overall, PPC was seen in 20 patients (13.4%) and rhinosinusitis in 10 patients (6.7%). Propensity matching generated 39 patients reconstructed with ADA and 39 reconstructed with mucosa. There was a significant increase in PPC in patients reconstructed with ADA compared to those reconstructed with mucosa (8 of 39 [20.5%] vs 2 of 39 [5.1%], p = 0.04). There was no association between reconstruction with ADA and increased rhinosinusitis (3 of 39 [7.7%] vs 4 of 39 [10.3%], p = 0.64). Conclusion: Sinonasal morbidity is not uncommon after sellar reconstruction. Patients undergoing sellar reconstruction with ADA may be at increased risk of postoperative crusting compared with those undergoing reconstruction with mucosa.

Original languageEnglish (US)
Pages (from-to)1178-1185
Number of pages8
JournalInternational Forum of Allergy and Rhinology
Issue number12
StatePublished - Dec 2017


  • Grafts
  • Morbidity
  • Mucosal graft
  • Postoperative crusting
  • endoscopic endonasal approach to the pituitary
  • endoscopic skull base surgery
  • postoperative
  • skull base repair

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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