Postmenopausal hormone therapy and Alzheimer's disease risk: Interaction with age

Victor W. Henderson, K. S. Benke, R. C. Green, L. A. Cupples, L. A. Farrer

Research output: Contribution to journalArticlepeer-review

179 Scopus citations


We examined the relation between oestrogen containing hormone therapy (HT) used for more than 6 months and Alzheimer's disease (AD) risk in 971 postmenopausal women (426 AD patients, 545 relatives without dementia). There was a significant interaction between age and HT use on AD risk (p = 0.03). In stratified analyses, a significant protective association was seen only in the youngest age fertile (50-63 years; odds ratio = 0.35, 95% confidence interval = 0.19 to 0.66). Results must be considered cautiously in light of recent clinical trial evidence that oestrogen plus progestin increases dementia incidence in older post-menopausal women. However, our observational findings are consistent with the view that HT may protect younger women from AD or reduce the risk of early onset forms of AD, or that HT used during the early postmenopause may reduce AD risk.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number1
StatePublished - Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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