Post-study caffeine administration enhances memory consolidation in humans

Daniel Borota, Elizabeth Murray, Gizem Keceli, Allen Chang, Joseph M. Watabe, Maria Ly, John P. Toscano, Michael A. Yassa

Research output: Contribution to journalArticlepeer-review


It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

Original languageEnglish (US)
Pages (from-to)201-203
Number of pages3
JournalNature neuroscience
Issue number2
StatePublished - Feb 2014

ASJC Scopus subject areas

  • General Neuroscience


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