Abstract
With the advent of next-generation sequencing technologies, there has been a dramatic increase in the availability of paired clinical and transcriptomic data in a variety of disease states. For basic science researchers, this has provided a valuable opportunity for querying the impact of the transcript levels of a gene on disease survival in humans. However, there are a multitude of methodological and technical considerations to evaluate before embarking on these analyses. Herein, we provide a brief description of statistical considerations involved in these analyses, geared toward basic scientists who may not necessarily routinely use such statistical models as part of their studies.
Original language | English (US) |
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Pages (from-to) | L1-L4 |
Journal | American Journal of Physiology - Lung Cellular and Molecular Physiology |
Volume | 324 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2023 |
Keywords
- Kaplan–Meier
- RNAseq
- survival
ASJC Scopus subject areas
- Physiology (medical)
- Physiology
- Pulmonary and Respiratory Medicine
- Cell Biology