Post-ECT increases in MRI regional T2 relaxation times and their relationship to cognitive side effects: A pilot study

David J. Diehl; Matcheri S. Keshavan; Emanuel Kanal; Robert D. Nebes; Thomas E. Nichols; Joseph S. Gillen

doi:10.1016/0165-1781(94)90005-1

Post-ECT increases in MRI regional T₂ relaxation times and their relationship to cognitive side effects: A pilot study

David J. Diehl, Matcheri S. Keshavan, Emanuel Kanal, Robert D. Nebes, Thomas E. Nichols, Joseph S. Gillen

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

This pilot study examined the hypothesis that magnetic resonance imaging T₂ relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T₂ increases in the right and left thalumus, and suggest a correlation between regional T₂ increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.

Original language	English (US)
Pages (from-to)	177-184
Number of pages	8
Journal	Psychiatry research
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(94)90005-1
State	Published - Nov 1994
Externally published	Yes

Keywords

Affective disorder
ECT
magnetic resonance imaging
memory
thalamus

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/0165-1781(94)90005-1

Cite this

@article{eb968feb3e1e493eb612b47fd7b2d7a8,

title = "Post-ECT increases in MRI regional T2 relaxation times and their relationship to cognitive side effects: A pilot study",

abstract = "This pilot study examined the hypothesis that magnetic resonance imaging T2 relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T2 increases in the right and left thalumus, and suggest a correlation between regional T2 increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.",

keywords = "Affective disorder, ECT, magnetic resonance imaging, memory, thalamus",

author = "Diehl, {David J.} and Keshavan, {Matcheri S.} and Emanuel Kanal and Nebes, {Robert D.} and Nichols, {Thomas E.} and Gillen, {Joseph S.}",

note = "Funding Information: Acknowledgments. This research was supported by grant MH-30915 from the National Institute of Mental Health . The authors thank the WPIC ECT physicians Robert Dealt', Paul Soloff, Hind Rifai, and Benoit Mulsant and the ECT nursing staff, especially Laverne DeJean and Carol Devise . They also thank Barbara Zambon, Amy Diehl, and Melissa Zeigler for assistance and Kathie Antonetti for preparation of the manuscript .",

year = "1994",

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AU - Diehl, David J.

AU - Keshavan, Matcheri S.

AU - Kanal, Emanuel

AU - Nebes, Robert D.

AU - Nichols, Thomas E.

AU - Gillen, Joseph S.

N1 - Funding Information: Acknowledgments. This research was supported by grant MH-30915 from the National Institute of Mental Health . The authors thank the WPIC ECT physicians Robert Dealt', Paul Soloff, Hind Rifai, and Benoit Mulsant and the ECT nursing staff, especially Laverne DeJean and Carol Devise . They also thank Barbara Zambon, Amy Diehl, and Melissa Zeigler for assistance and Kathie Antonetti for preparation of the manuscript .

PY - 1994/11

Y1 - 1994/11

N2 - This pilot study examined the hypothesis that magnetic resonance imaging T2 relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T2 increases in the right and left thalumus, and suggest a correlation between regional T2 increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.

AB - This pilot study examined the hypothesis that magnetic resonance imaging T2 relaxation times of specific brain regions increase after electroconvulsive therapy (ECT) and that these increases are related to the cognitive side effects of ECT. Six depressed patients undergoing unilateral ECT were studied. The results demonstrate significant post-ECT T2 increases in the right and left thalumus, and suggest a correlation between regional T2 increase and anterograde memory impairment following ECT. These findings are consistent with a post-ECT increase in brain water content (perhaps secondary to a breakdown of the blood-brain barrier) and suggest that this process may be related to the memory impairment following ECT.

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KW - memory

KW - thalamus

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