Positron emission tomography molecular imaging in late-life depression

Kentaro Hirao, Gwenn S. Smith

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Molecular imaging represents a bridge between basic and clinical neuroscience observations and provides many opportunities for translation and identifying mechanisms that may inform prevention and intervention strategies in late-life depression (LLD). Substantial advances in instrumentation and radiotracer chemistry have resulted in improved sensitivity and spatial resolution and the ability to study in vivo an increasing number of neurotransmitters, neuromodulators, and, importantly, neuropathological processes. Molecular brain imaging studies in LLD will be reviewed, with a primary focus on positron emission tomography. Future directions for the field of molecular imaging in LLD will be discussed, including integrating molecular imaging with genetic, neuropsychiatric, and cognitive outcomes and multimodality neuroimaging.

Original languageEnglish (US)
Pages (from-to)13-23
Number of pages11
JournalJournal of Geriatric Psychiatry and Neurology
Issue number1
StatePublished - Mar 2014


  • acetylcholine
  • depression
  • dopamine
  • molecular imaging
  • positron emission tomography
  • serotonin

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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