Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles

Huabing Sun, Liwei Zheng, Kun Yang, Marc M. Greenberg

Research output: Contribution to journalArticlepeer-review


Electron deficient "holes" migrate over long distances through the π-system in free DNA. Hole transfer efficiency (HTE) is strongly dependent on sequence and π-stacking. However, there is no consensus regarding the effects of nucleosome core particle (NCP) environment on hole migration. We quantitatively determined HTE in free DNA and NCPs by independently generating holes at specific positions in DNA. The relative HTE varied widely with respect to position within the NCP and proximity to tyrosine, which suppresses hole transfer. These data indicate that hole transfer in chromatin will be affected by the DNA sequence and its position with respect to histone proteins within NCPs.

Original languageEnglish (US)
Pages (from-to)10154-10158
Number of pages5
JournalJournal of the American Chemical Society
Issue number26
StatePublished - Jul 3 2019

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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