Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Brahm H. Segal; Lisa A. Barnhart; Victoria L. Anderson; Thomas J. Walsh; Harry L. Malech; Steven M. Holland

doi:10.1086/430068

Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Brahm H. Segal, Lisa A. Barnhart, Victoria L. Anderson, Thomas J. Walsh, Harry L. Malech, Steven M. Holland

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

Original language	English (US)
Pages (from-to)	1684-1688
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	40
Issue number	11
DOIs	https://doi.org/10.1086/430068
State	Published - Jun 1 2005
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/430068

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abstract = "Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.",

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AU - Malech, Harry L.

AU - Holland, Steven M.

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AB - Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

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Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Abstract

ASJC Scopus subject areas

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