TY - JOUR
T1 - Population frequency distributions of HDL, HDL2, and HDL3 cholesterol and apolipoproteins A-I and B in healthy men and women and associations with age, gender, hormonal status, and sex hormone use
T2 - The Stanford Five City Project
AU - Gardner, Christopher D.
AU - Tribble, Diane L.
AU - Young, Deborah Rohm
AU - Ahn, David
AU - Fortmann, Stephen P.
N1 - Funding Information:
1The Stanford Five City Project was supported by Public Health Service Grant HL21906 from the National Heart, Lung, and Blood Institute. Dr. Gardner was supported by Institutional National Research Service Award 5 T32 HL07034, from the National Heart, Lung, and Blood Institute, and by a Postdoctoral Fellowship Award from the American Heart Association, California Affiliate, No. 95-89. Dr. Tribble was supported by Public Health Service Grant Hl54606-01A1.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Background. The purpose of this study is to present population-based frequency distribution data for several lipoprotein-related variables and to examine their associations with gender, age, menopausal status, and sex hormone use. Methods. High-density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, apolipoprotein (Apo) A-I, and Apo B were measured in a population-based sample of 1,027 healthy adults from four California cities who participated in the 1989-1990 survey of the Stanford Five City Project. These data were examined cross-sectionally with sociodemographic and other related variables. Results. Relative to men, all of the HDL-related parameters - HDL-C, HDL2-C, HDL3-C, Apo A-I - were significantly higher and Apo B levels were significantly lower among women (P < 0.001). Menopausal status was not associated with HDL-related parameters, but Apo B levels were higher in post- versus premenopausal women (P < 0.001). Among women, HDL-C and Apo A-I levels were higher in oral contraceptive and estrogen replacement therapy users (P = 0.003). Most of the significant findings remained statistically significant after adjusting for age, body mass index, smoking, energy expenditure, and alcohol intake. Conclusions. These population-based data indicate that gender, menopausal status, and the use of sex hormones among women are associated with differential levels of one or more of HDL-C, HDL2-C, HDL3-C, Apo A-I, and Apo B, independent of age and a broad set of lifestyle factors. (C) 2000 American Health Foundation and Academic Press.
AB - Background. The purpose of this study is to present population-based frequency distribution data for several lipoprotein-related variables and to examine their associations with gender, age, menopausal status, and sex hormone use. Methods. High-density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, apolipoprotein (Apo) A-I, and Apo B were measured in a population-based sample of 1,027 healthy adults from four California cities who participated in the 1989-1990 survey of the Stanford Five City Project. These data were examined cross-sectionally with sociodemographic and other related variables. Results. Relative to men, all of the HDL-related parameters - HDL-C, HDL2-C, HDL3-C, Apo A-I - were significantly higher and Apo B levels were significantly lower among women (P < 0.001). Menopausal status was not associated with HDL-related parameters, but Apo B levels were higher in post- versus premenopausal women (P < 0.001). Among women, HDL-C and Apo A-I levels were higher in oral contraceptive and estrogen replacement therapy users (P = 0.003). Most of the significant findings remained statistically significant after adjusting for age, body mass index, smoking, energy expenditure, and alcohol intake. Conclusions. These population-based data indicate that gender, menopausal status, and the use of sex hormones among women are associated with differential levels of one or more of HDL-C, HDL2-C, HDL3-C, Apo A-I, and Apo B, independent of age and a broad set of lifestyle factors. (C) 2000 American Health Foundation and Academic Press.
KW - Apolipoproteins
KW - Diet
KW - Epidemiology
KW - Exercise
KW - Hormones
KW - Lifestyle
KW - Lipids
KW - Lipoprot eins
KW - Men
KW - Risk factors
KW - Smoking
KW - Women
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U2 - 10.1006/pmed.2000.0715
DO - 10.1006/pmed.2000.0715
M3 - Article
C2 - 11006058
AN - SCOPUS:0033815723
SN - 0091-7435
VL - 31
SP - 335
EP - 345
JO - Preventive Medicine
JF - Preventive Medicine
IS - 4
ER -