Pooling data when analyzing biomarkers subject to a limit of detection

Leslie Rosenthal, Enrique Schisterman

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


The use of biomarkers to assess exposure and investigate biomedical questions is common in epidemiology. The usefulness of biomarker research, however, is contingent upon the ability to achieve a complete understanding of the role they play within a population. In estimating distributional parameters for a particular biomarker, such as oxidative stress or antioxidant markers, scientists face two main challenges: overcoming the cost of performing a large number of assays and dealing with data subject to a limit of detection. While approaches have been suggested to deal with each of these issues individually, pooling is a strategy that can address both problems.

Original languageEnglish (US)
Title of host publicationAdvanced Protocols in Oxidative Stress I
EditorsDonald Armstrong, Donald Armstrong, Donald Armstrong
Number of pages6
StatePublished - 2008
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Biomarkers
  • Detection limit
  • Pooling

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology


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