Poly(α-hydroxy ester)/short fiber hydroxyapatite composite foams for orthopedic application

Robert C. Thomson; Michael J. Yaszemski; John M. Powers; Timothy P. Harrigan; Antonios G. Mikos

Poly(α-hydroxy ester)/short fiber hydroxyapatite composite foams for orthopedic application

Robert C. Thomson, Michael J. Yaszemski, John M. Powers, Timothy P. Harrigan, Antonios G. Mikos

Research output: Contribution to journal › Conference article › peer-review

Abstract

A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The technique allows the manufacture of 3D foam scaffolds and involves the formation of a composite material consisting of a porogen material and hydroxyapatite short fibers embedded in a PLGA matrix. The porogen is initially leached out, then an opencell composite foam remains, which has a pore size and morphology defined by the porogen. The foam porosity can be controlled by altering the volume fraction of the porogen used to make the composite material. The foams are made using various porogen materials. The composite foams may be expected to enhance osteoconductivity and hence provide a novel material that may be useful in the field of bone regeneration.

Original language	English (US)
Pages (from-to)	25-30
Number of pages	6
Journal	Materials Research Society Symposium - Proceedings
Volume	394
State	Published - Dec 1 1995
Externally published	Yes
Event	Proceedings of the 1995 MRS Spring Meeting - San Francisco, CA, USA Duration: Apr 17 1995 → Apr 21 1995

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Poly(α-hydroxy ester)/short fiber hydroxyapatite composite foams for orthopedic application",

abstract = "A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The technique allows the manufacture of 3D foam scaffolds and involves the formation of a composite material consisting of a porogen material and hydroxyapatite short fibers embedded in a PLGA matrix. The porogen is initially leached out, then an opencell composite foam remains, which has a pore size and morphology defined by the porogen. The foam porosity can be controlled by altering the volume fraction of the porogen used to make the composite material. The foams are made using various porogen materials. The composite foams may be expected to enhance osteoconductivity and hence provide a novel material that may be useful in the field of bone regeneration.",

author = "Thomson, {Robert C.} and Yaszemski, {Michael J.} and Powers, {John M.} and Harrigan, {Timothy P.} and Mikos, {Antonios G.}",

year = "1995",

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language = "English (US)",

volume = "394",

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journal = "Materials Research Society Symposium - Proceedings",

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note = "Proceedings of the 1995 MRS Spring Meeting ; Conference date: 17-04-1995 Through 21-04-1995",

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TY - JOUR

T1 - Poly(α-hydroxy ester)/short fiber hydroxyapatite composite foams for orthopedic application

AU - Thomson, Robert C.

AU - Yaszemski, Michael J.

AU - Powers, John M.

AU - Harrigan, Timothy P.

AU - Mikos, Antonios G.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The technique allows the manufacture of 3D foam scaffolds and involves the formation of a composite material consisting of a porogen material and hydroxyapatite short fibers embedded in a PLGA matrix. The porogen is initially leached out, then an opencell composite foam remains, which has a pore size and morphology defined by the porogen. The foam porosity can be controlled by altering the volume fraction of the porogen used to make the composite material. The foams are made using various porogen materials. The composite foams may be expected to enhance osteoconductivity and hence provide a novel material that may be useful in the field of bone regeneration.

AB - A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The technique allows the manufacture of 3D foam scaffolds and involves the formation of a composite material consisting of a porogen material and hydroxyapatite short fibers embedded in a PLGA matrix. The porogen is initially leached out, then an opencell composite foam remains, which has a pore size and morphology defined by the porogen. The foam porosity can be controlled by altering the volume fraction of the porogen used to make the composite material. The foams are made using various porogen materials. The composite foams may be expected to enhance osteoconductivity and hence provide a novel material that may be useful in the field of bone regeneration.

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M3 - Conference article

AN - SCOPUS:0029474489

SN - 0272-9172

VL - 394

SP - 25

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JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - Proceedings of the 1995 MRS Spring Meeting

Y2 - 17 April 1995 through 21 April 1995

ER -

Poly(α-hydroxy ester)/short fiber hydroxyapatite composite foams for orthopedic application

Abstract

ASJC Scopus subject areas

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