TY - JOUR
T1 - Polysubstance abuse-vulnerability genes
T2 - Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms
AU - Uhl, G. R.
AU - Liu, Q. R.
AU - Walther, D.
AU - Hess, J.
AU - Naiman, D.
PY - 2001
Y1 - 2001
N2 - Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.
AB - Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.
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U2 - 10.1086/324467
DO - 10.1086/324467
M3 - Article
C2 - 11704927
AN - SCOPUS:0035209299
SN - 0002-9297
VL - 69
SP - 1290
EP - 1300
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 6
ER -