@article{41e1e97a975d414b9d58edb52fe55409,
title = "Polyphenols journey through blood-brain barrier towards neuronal protection",
abstract = "Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to influence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for differential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and inflammatory injuries and this attenuation of neuroinflammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated inflammation and exert neuroprotective effects, with potential for alleviation of neurodegenerative diseases.",
author = "I. Figueira and G. Garcia and Pimp{\~a}o, {R. C.} and Terrasso, {A. P.} and I. Costa and Almeida, {A. F.} and L. Tavares and Pais, {T. F.} and P. Pinto and Ventura, {M. R.} and A. Filipe and McDougall, {G. J.} and D. Stewart and Kim, {K. S.} and I. Palmela and D. Brites and Brito, {M. A.} and C. Brito and Santos, {C. N.}",
note = "Funding Information: iNOVA4Health Research Unit (LISBOA-01–0145-FEDER-007344), which is cofunded by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia/Minist{\'e}rio da Ci{\^e}ncia e do Ensino Superior, through national funds, and by FEDER under the PT2020 Partnership Agreement, is acknowledged. Authors would like to acknowledge to COST Action FA1005–INFOGEST and COST Action FA1403–POSITIVe for the funding of STSM, supported by COST (European Cooperation in Science and Technology). To FCT for financial support of CNS (IF/01097/2013), IF (SFRH/BD/86584/2012), APT (PD/BD/52473/2014), RP (SFRH/BD/63615/2009), and IP, DB and MAB (Strategic Project to iMed.ULisboa, UID/DTP/04138/2013). CNS and DS acknowledge funding via BacHBerry (Project No. FP7-613793; www.bachberry.eu) and DS and GMcD acknowledge funding from the Scottish Government Rural Affairs and Environment Strategic Research. Funding from Tecnimede - Sociedade T{\'e}cnico Medicinal S.A. (Abrunheira, Sintra, Portugal), the European Regional Development Fund (FEDER) and the System of Incentives for the Research and Technological Development (QREN) of the Portuguese Government is also acknowledged. We would also like to thank to Ana Carina Silva for technical support and to Dr. Lidia Gon{\c c}alves for the access to the FLUOstar Omega fluorescent plate reader. We also acknowledge Dr. Helena L.A. Vieira by animal manipulation and handling. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41598-017-11512-6",
language = "English (US)",
volume = "7",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}