Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China

Min Shen; Sonja I. Berndt; Nathaniel Rothman; Judy L. Mumford; Xingzhou He; Meredith Yeager; Robert Welch; Stephen Chanock; Phouthone Keohavong; Mark Donahue; Tongzhang Zheng; Neil Caporaso; Qing Lan

Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China

Min Shen, Sonja I. Berndt, Nathaniel Rothman, Judy L. Mumford, Xingzhou He, Meredith Yeager, Robert Welch, Stephen Chanock, Phouthone Keohavong, Mark Donahue, Tongzhang Zheng, Neil Caporaso, Qing Lan

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions, which contain high levels of PAHs and can lead to modified bases. We studied genetic polymorphisms in four DNA base excision repair genes in a population-based case-control study in Xuan Wei with 122 lung cancer cases and 122 controls. Homozygous earners of the APEX1 148Glu variant had an increased risk (OR, 2.13; 95% CI, 0.96-4.74), whereas persons with the XRCC1 399Gln allele had a decreased risk (OR, 0.60; 95% CI, 0.35-1.02) of lung cancer compared with wild-type carriers. Subjects with both at-risk genotypes (APEX1 Glu148Glu and XRCC1 Arg399Arg) had a higher risk of lung cancer (OR: 3.34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China.

Original language	English (US)
Pages (from-to)	537-542
Number of pages	6
Journal	Anticancer research
Volume	25
Issue number	1 B
State	Published - Jan 2005
Externally published	Yes

Keywords

ADPRT
APEX1
DNA repair
LIG3
Lung cancer
Single nucleotide polymorphism
XRCC1

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{a8532c8965f64ef9895866aa0dd8fe8a,

title = "Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China",

abstract = "The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions, which contain high levels of PAHs and can lead to modified bases. We studied genetic polymorphisms in four DNA base excision repair genes in a population-based case-control study in Xuan Wei with 122 lung cancer cases and 122 controls. Homozygous earners of the APEX1 148Glu variant had an increased risk (OR, 2.13; 95% CI, 0.96-4.74), whereas persons with the XRCC1 399Gln allele had a decreased risk (OR, 0.60; 95% CI, 0.35-1.02) of lung cancer compared with wild-type carriers. Subjects with both at-risk genotypes (APEX1 Glu148Glu and XRCC1 Arg399Arg) had a higher risk of lung cancer (OR: 3.34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China.",

keywords = "ADPRT, APEX1, DNA repair, LIG3, Lung cancer, Single nucleotide polymorphism, XRCC1",

author = "Min Shen and Berndt, {Sonja I.} and Nathaniel Rothman and Mumford, {Judy L.} and Xingzhou He and Meredith Yeager and Robert Welch and Stephen Chanock and Phouthone Keohavong and Mark Donahue and Tongzhang Zheng and Neil Caporaso and Qing Lan",

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month = jan,

language = "English (US)",

volume = "25",

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journal = "Anticancer research",

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publisher = "International Institute of Anticancer Research",

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T1 - Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China

AU - Shen, Min

AU - Berndt, Sonja I.

AU - Rothman, Nathaniel

AU - Mumford, Judy L.

AU - He, Xingzhou

AU - Yeager, Meredith

AU - Welch, Robert

AU - Chanock, Stephen

AU - Keohavong, Phouthone

AU - Donahue, Mark

AU - Zheng, Tongzhang

AU - Caporaso, Neil

AU - Lan, Qing

PY - 2005/1

Y1 - 2005/1

N2 - The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions, which contain high levels of PAHs and can lead to modified bases. We studied genetic polymorphisms in four DNA base excision repair genes in a population-based case-control study in Xuan Wei with 122 lung cancer cases and 122 controls. Homozygous earners of the APEX1 148Glu variant had an increased risk (OR, 2.13; 95% CI, 0.96-4.74), whereas persons with the XRCC1 399Gln allele had a decreased risk (OR, 0.60; 95% CI, 0.35-1.02) of lung cancer compared with wild-type carriers. Subjects with both at-risk genotypes (APEX1 Glu148Glu and XRCC1 Arg399Arg) had a higher risk of lung cancer (OR: 3.34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China.

AB - The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions, which contain high levels of PAHs and can lead to modified bases. We studied genetic polymorphisms in four DNA base excision repair genes in a population-based case-control study in Xuan Wei with 122 lung cancer cases and 122 controls. Homozygous earners of the APEX1 148Glu variant had an increased risk (OR, 2.13; 95% CI, 0.96-4.74), whereas persons with the XRCC1 399Gln allele had a decreased risk (OR, 0.60; 95% CI, 0.35-1.02) of lung cancer compared with wild-type carriers. Subjects with both at-risk genotypes (APEX1 Glu148Glu and XRCC1 Arg399Arg) had a higher risk of lung cancer (OR: 3.34; 95% CI: 1.16-9.67). We found genetic variants in APEX1 and XRCC1 may alter the risk of lung cancer in a special population in China.

KW - ADPRT

KW - APEX1

KW - DNA repair

KW - LIG3

KW - Lung cancer

KW - Single nucleotide polymorphism

KW - XRCC1

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ER -

Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China

Abstract

Keywords

ASJC Scopus subject areas

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