TY - JOUR
T1 - Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma
AU - Chen, Yingtai
AU - Lan, Qing
AU - Zheng, Tongzhang
AU - Zhao, Nan
AU - Holford, Theodore R.
AU - Lerro, Catherine
AU - Dai, Min
AU - Huang, Huang
AU - Liang, Jiaxin
AU - Ma, Shuangge
AU - Leaderer, Brian
AU - Boyle, Peter
AU - Chanock, Stephen
AU - Rothman, Nathaniel
AU - Zhang, Yawei
N1 - Funding Information:
This research was supported by the NIH grants CA62006 , CA165923 , 1D43TW008323 , 1D43TW007864 , and HD70324 , and the Intramural Research Program of the National Cancer Institute.
PY - 2013/9
Y1 - 2013/9
N2 - Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.
AB - Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.
KW - Case-control study
KW - JAK/STAT signaling pathway
KW - Non-Hodgkin lymphoma
KW - Polymorphism
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U2 - 10.1016/j.leukres.2013.05.003
DO - 10.1016/j.leukres.2013.05.003
M3 - Article
C2 - 23768868
AN - SCOPUS:84880939854
SN - 0145-2126
VL - 37
SP - 1120
EP - 1124
JO - Leukemia Research
JF - Leukemia Research
IS - 9
ER -