Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China

Min Shen; Nathaniel Rothman; Sonja I. Berndt; Xingzhou He; Meredith Yeager; Robert Welch; Stephen Chanock; Neil Caporaso; Qing Lan

doi:10.1016/j.lungcan.2005.04.002

Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China

Min Shen, Nathaniel Rothman, Sonja I. Berndt, Xingzhou He, Meredith Yeager, Robert Welch, Stephen Chanock, Neil Caporaso, Qing Lan

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The aim of this study is to investigate the role of genetic polymorphisms in twelve folate metabolism genes on the risk of lung cancer in Xuan Wei, China, where the lung cancer mortality rate is among the highest and is mainly caused by indoor smoky coal emissions. A total of 122 incident primary lung cancer cases and 122 matched controls were enrolled. Three single nucleotide polymorphisms were associated with increased risk of lung cancer including homozygotes of the C allele of CBS Ala360Ala (OR: 4.02; 95% CI: 1.64-9.87), the 222Val allele of MTHFR (OR: 2.32; 95% CI: 1.34-4.03), and the C allele of SLC19A1 Pro232Pro (OR: 1.83; 95% CI: 1.02-3.28). The distribution of CBS and MTHFR haplotypes differed between cases and controls (P = 0.002 and P = 0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China.

Original language	English (US)
Pages (from-to)	299-309
Number of pages	11
Journal	Lung Cancer
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2005.04.002
State	Published - Sep 2005
Externally published	Yes

Keywords

Folate metabolism
Haplotype
Lung cancer
Polycyclic aromatic hydrocarbon
Single nucleotide polymorphism

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/j.lungcan.2005.04.002

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title = "Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China",

abstract = "The aim of this study is to investigate the role of genetic polymorphisms in twelve folate metabolism genes on the risk of lung cancer in Xuan Wei, China, where the lung cancer mortality rate is among the highest and is mainly caused by indoor smoky coal emissions. A total of 122 incident primary lung cancer cases and 122 matched controls were enrolled. Three single nucleotide polymorphisms were associated with increased risk of lung cancer including homozygotes of the C allele of CBS Ala360Ala (OR: 4.02; 95% CI: 1.64-9.87), the 222Val allele of MTHFR (OR: 2.32; 95% CI: 1.34-4.03), and the C allele of SLC19A1 Pro232Pro (OR: 1.83; 95% CI: 1.02-3.28). The distribution of CBS and MTHFR haplotypes differed between cases and controls (P = 0.002 and P = 0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China.",

keywords = "Folate metabolism, Haplotype, Lung cancer, Polycyclic aromatic hydrocarbon, Single nucleotide polymorphism",

author = "Min Shen and Nathaniel Rothman and Berndt, {Sonja I.} and Xingzhou He and Meredith Yeager and Robert Welch and Stephen Chanock and Neil Caporaso and Qing Lan",

year = "2005",

month = sep,

doi = "10.1016/j.lungcan.2005.04.002",

language = "English (US)",

volume = "49",

pages = "299--309",

journal = "Lung Cancer",

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T1 - Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China

AU - Shen, Min

AU - Rothman, Nathaniel

AU - Berndt, Sonja I.

AU - He, Xingzhou

AU - Yeager, Meredith

AU - Welch, Robert

AU - Chanock, Stephen

AU - Caporaso, Neil

AU - Lan, Qing

PY - 2005/9

Y1 - 2005/9

N2 - The aim of this study is to investigate the role of genetic polymorphisms in twelve folate metabolism genes on the risk of lung cancer in Xuan Wei, China, where the lung cancer mortality rate is among the highest and is mainly caused by indoor smoky coal emissions. A total of 122 incident primary lung cancer cases and 122 matched controls were enrolled. Three single nucleotide polymorphisms were associated with increased risk of lung cancer including homozygotes of the C allele of CBS Ala360Ala (OR: 4.02; 95% CI: 1.64-9.87), the 222Val allele of MTHFR (OR: 2.32; 95% CI: 1.34-4.03), and the C allele of SLC19A1 Pro232Pro (OR: 1.83; 95% CI: 1.02-3.28). The distribution of CBS and MTHFR haplotypes differed between cases and controls (P = 0.002 and P = 0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China.

AB - The aim of this study is to investigate the role of genetic polymorphisms in twelve folate metabolism genes on the risk of lung cancer in Xuan Wei, China, where the lung cancer mortality rate is among the highest and is mainly caused by indoor smoky coal emissions. A total of 122 incident primary lung cancer cases and 122 matched controls were enrolled. Three single nucleotide polymorphisms were associated with increased risk of lung cancer including homozygotes of the C allele of CBS Ala360Ala (OR: 4.02; 95% CI: 1.64-9.87), the 222Val allele of MTHFR (OR: 2.32; 95% CI: 1.34-4.03), and the C allele of SLC19A1 Pro232Pro (OR: 1.83; 95% CI: 1.02-3.28). The distribution of CBS and MTHFR haplotypes differed between cases and controls (P = 0.002 and P = 0.07, respectively). In summary, three genetic variants in folate metabolism genes are associated with an increased risk of lung cancer in Xuan Wei, China.

KW - Folate metabolism

KW - Haplotype

KW - Lung cancer

KW - Polycyclic aromatic hydrocarbon

KW - Single nucleotide polymorphism

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Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China

Abstract

Keywords

ASJC Scopus subject areas

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