Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma

Yingtai Chen; Tongzhang Zheng; Qing Lan; Christopher Kim; Qin Qin; Francine Foss; Xuezhong Chen; Theodore Holford; Brian Leaderer; Peter Boyle; Chengfeng Wang; Min Dai; Zhenjiang Liu; Shuangge Ma; Stephen J. Chanock; Nathaniel Rothman; Yawei Zhang

doi:10.1002/ajh.23463

Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma

Yingtai Chen, Tongzhang Zheng, Qing Lan, Christopher Kim, Qin Qin, Francine Foss, Xuezhong Chen, Theodore Holford, Brian Leaderer, Peter Boyle, Chengfeng Wang, Min Dai, Zhenjiang Liu, Shuangge Ma, Stephen J. Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

Original language	English (US)
Pages (from-to)	606-611
Number of pages	6
Journal	American journal of hematology
Volume	88
Issue number	7
DOIs	https://doi.org/10.1002/ajh.23463
State	Published - Jul 2013
Externally published	Yes

ASJC Scopus subject areas

Hematology

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title = "Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma",

abstract = "We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.",

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year = "2013",

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doi = "10.1002/ajh.23463",

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pages = "606--611",

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AU - Chen, Yingtai

AU - Zheng, Tongzhang

AU - Lan, Qing

AU - Kim, Christopher

AU - Qin, Qin

AU - Foss, Francine

AU - Chen, Xuezhong

AU - Holford, Theodore

AU - Leaderer, Brian

AU - Boyle, Peter

AU - Wang, Chengfeng

AU - Dai, Min

AU - Liu, Zhenjiang

AU - Ma, Shuangge

AU - Chanock, Stephen J.

AU - Rothman, Nathaniel

AU - Zhang, Yawei

PY - 2013/7

Y1 - 2013/7

N2 - We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

AB - We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.

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Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma

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