TY - JOUR
T1 - Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut
AU - Shen, Min
AU - Zheng, Tongzhang
AU - Lan, Qing
AU - Zhang, Yawei
AU - Zahm, Shelia H.
AU - Wang, Sophia S.
AU - Holford, Theodore R.
AU - Leaderer, Brian
AU - Yeager, Meredith
AU - Welch, Robert
AU - Kang, Daehee
AU - Boyle, Peter
AU - Zhang, Bing
AU - Zou, Kaiyong
AU - Zhu, Yong
AU - Chanock, Stephen
AU - Rothman, Nathaniel
N1 - Funding Information:
Acknowledgements This study was supported by the NIH grant CA62006 (T. Zheng) and in part by the Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute. We thank Dr. Bingshu Eric Chen for the statistical consultation for this study.
PY - 2006/7
Y1 - 2006/7
N2 - Several hereditary syndromes characterized by defective DNA repair are associated with high risk of non-Hodgkin lymphoma (NHL). To explore whether common polymorphisms in DNA repair genes affect risk of NHL in the general population, we evaluated the association between single nucleotide polymorphisms (SNPs) in DNA repair genes and risk of NHL in a population-based case-control study among women in Connecticut. A total of 518 NHL cases and 597 controls recruited into the study provided a biologic sample. Thirty-two SNPs in 18 genes involved in several DNA repair pathways were genotyped. Genotype data were analyzed by unconditional logistic regression adjusting for age and race. SNPs in four genes (ERCC5, ERCC2, WRN, and BRCA1) were associated with altered risk of NHL and diffuse large B-cell lymphoma (DLBCL), the major B cell subtype. In particular, ERCC5 Asp1104His was associated with increased risk of NHL overall (OR: 1.46; 95% CI: 1.13-1.88; P = 0.004), DLBCL (OR: 1.44; 95% CI: 0.99-2.09; P = 0.058), and also T cell lymphoma. WRN Cys1367Arg was associated with decreased risk of NHL overall (OR: 0.71; 95% CI: 0.56-0.91; P = 0.007) and DLBCL (OR: 0.66; 95% CI: 0.45-0.95; P = 0.024), as well as follicular and marginal zone lymphomas. Genetic polymorphisms in DNA repair genes, particularly ERCC5 and WRN, may play a role in the pathogenesis of NHL, especially for DLBCL. Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies.
AB - Several hereditary syndromes characterized by defective DNA repair are associated with high risk of non-Hodgkin lymphoma (NHL). To explore whether common polymorphisms in DNA repair genes affect risk of NHL in the general population, we evaluated the association between single nucleotide polymorphisms (SNPs) in DNA repair genes and risk of NHL in a population-based case-control study among women in Connecticut. A total of 518 NHL cases and 597 controls recruited into the study provided a biologic sample. Thirty-two SNPs in 18 genes involved in several DNA repair pathways were genotyped. Genotype data were analyzed by unconditional logistic regression adjusting for age and race. SNPs in four genes (ERCC5, ERCC2, WRN, and BRCA1) were associated with altered risk of NHL and diffuse large B-cell lymphoma (DLBCL), the major B cell subtype. In particular, ERCC5 Asp1104His was associated with increased risk of NHL overall (OR: 1.46; 95% CI: 1.13-1.88; P = 0.004), DLBCL (OR: 1.44; 95% CI: 0.99-2.09; P = 0.058), and also T cell lymphoma. WRN Cys1367Arg was associated with decreased risk of NHL overall (OR: 0.71; 95% CI: 0.56-0.91; P = 0.007) and DLBCL (OR: 0.66; 95% CI: 0.45-0.95; P = 0.024), as well as follicular and marginal zone lymphomas. Genetic polymorphisms in DNA repair genes, particularly ERCC5 and WRN, may play a role in the pathogenesis of NHL, especially for DLBCL. Further work is needed to extend these findings by carrying out extended haplotype analyses of these and related genes and to replicate the observations in other studies.
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U2 - 10.1007/s00439-006-0177-2
DO - 10.1007/s00439-006-0177-2
M3 - Article
C2 - 16738949
AN - SCOPUS:33744464558
SN - 0340-6717
VL - 119
SP - 659
EP - 668
JO - Human genetics
JF - Human genetics
IS - 6
ER -