Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

Shashwath A. Meda; Joel Gelernter; Jeffrey R. Gruen; Vince D. Calhoun; Haiying Meng; Natalie A. Cope; Godfrey D. Pearlson

doi:10.1007/s11682-007-9012-1

Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

Shashwath A. Meda, Joel Gelernter, Jeffrey R. Gruen, Vince D. Calhoun, Haiying Meng, Natalie A. Cope, Godfrey D. Pearlson

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

Original language	English (US)
Pages (from-to)	21-26
Number of pages	6
Journal	Brain Imaging and Behavior
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/s11682-007-9012-1
State	Published - Mar 2008
Externally published	Yes

Keywords

Dyslexia
Language
Polymorphism
Structural imaging
VBM

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Neurology
Cognitive Neuroscience
Clinical Neurology
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Behavioral Neuroscience

Access to Document

10.1007/s11682-007-9012-1

Cite this

@article{fb9cfc90e59e4b11842fb77beed0f500,

title = "Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study",

abstract = "Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.",

keywords = "Dyslexia, Language, Polymorphism, Structural imaging, VBM",

author = "Meda, {Shashwath A.} and Joel Gelernter and Gruen, {Jeffrey R.} and Calhoun, {Vince D.} and Haiying Meng and Cope, {Natalie A.} and Pearlson, {Godfrey D.}",

note = "Funding Information: Acknowledgements The authors would like to thank Ann Marie Lacobelle and Greg Kay for technical assistance. This research was supported in part by grants from the National Institutes of Health, under RO1 grants MH60504, MH43775, MH52886 and an NIMH MERIT award (to GP) 1 R01 EB 000840 and 1 R01 EB 005846, R01 DA12690, R01 DA12849, K24 DA15105; 1 R01 NS43530 to JRG; the U.S. Department of Veterans Affairs (the VA Connecticut– Massachusetts Mental Illness Research, Education and Clinical Center [MIRECC]) to JG; a Hartford Hospital Open Grant Award, and a National Association for Research in Schizophrenia and Affective Disorders Young Investigator Award to VC.",

year = "2008",

month = mar,

doi = "10.1007/s11682-007-9012-1",

language = "English (US)",

volume = "2",

pages = "21--26",

journal = "Brain Imaging and Behavior",

issn = "1931-7557",

publisher = "Springer New York",

number = "1",

}

TY - JOUR

T1 - Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

AU - Meda, Shashwath A.

AU - Gelernter, Joel

AU - Gruen, Jeffrey R.

AU - Calhoun, Vince D.

AU - Meng, Haiying

AU - Cope, Natalie A.

AU - Pearlson, Godfrey D.

N1 - Funding Information: Acknowledgements The authors would like to thank Ann Marie Lacobelle and Greg Kay for technical assistance. This research was supported in part by grants from the National Institutes of Health, under RO1 grants MH60504, MH43775, MH52886 and an NIMH MERIT award (to GP) 1 R01 EB 000840 and 1 R01 EB 005846, R01 DA12690, R01 DA12849, K24 DA15105; 1 R01 NS43530 to JRG; the U.S. Department of Veterans Affairs (the VA Connecticut– Massachusetts Mental Illness Research, Education and Clinical Center [MIRECC]) to JG; a Hartford Hospital Open Grant Award, and a National Association for Research in Schizophrenia and Affective Disorders Young Investigator Award to VC.

PY - 2008/3

Y1 - 2008/3

N2 - Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

AB - Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

KW - Dyslexia

KW - Language

KW - Polymorphism

KW - Structural imaging

KW - VBM

UR - http://www.scopus.com/inward/record.url?scp=77949646703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949646703&partnerID=8YFLogxK

U2 - 10.1007/s11682-007-9012-1

DO - 10.1007/s11682-007-9012-1

M3 - Article

C2 - 19096528

AN - SCOPUS:77949646703

SN - 1931-7557

VL - 2

SP - 21

EP - 26

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - 1

ER -

Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this