Abstract
Background. Inflammation is a major cause of restenosis after coronary stenting. Intercellular adhesion molecule-1 (ICAM-1) is an important adhesion molecule that plays a key role in the tight adhesion between leukocytes and vascular endothelium. The object of this study was to investigate the association between the K469E polymorphism of the ICAM-1 gene and restenosis after coronary stenting in North Chinese population. Methods. The ICAM-1 K469E polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism method in 124 patients who had undergone coronary stenting and coronary angiography at least 3 months earlier. Information on clinical risk factors and procedure-related data were also collected. Results. Of 124 enrolled patients in total, there were 72 cases of in-stent restenosis. The restenosis rate in this population was 58.1%. The frequencies of the three possible genotypes of the ICAM-1 K469E polymorphism were: KK genotype 50.8%, EE genotype 41.9%, and EK genotype 41.9%. Among restenosis patients, the frequency of the KK genotype was 58.3% and the frequency of E allele carriers was 41.7%. Among non-restenosis patients, the frequency of the KK genotype was 40.4%, and the frequency of E allele carriers was 59.6%. The distribution of these two genotype groups between restenosis and non-restenosis patients was significantly different (P = 0.049). Using multivariate logistic regression, the difference between the two groups was more apparent. The odds ratio of KK homozygotes vs E allele carriers was 2.6, with 95% confidence interval 1.2-5.8 (P = 0.018). After grading of risk factors, we found that the KK genotype was a stronger predictor of instent restenosis in obesity or hyperlipemia patients, with an odds ratio of 9.3 and 3.7, respectively (P <0.05). Conclusion. In our study population, KK homozygotes of the ICAM-1 codon 469 mutation had a higher risk of restenosis after coronary stenting, especially in the case of obese or hyperlipemia patients.
Original language | English (US) |
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Pages (from-to) | 172-175 |
Number of pages | 4 |
Journal | Chinese medical journal |
Volume | 117 |
Issue number | 2 |
State | Published - Feb 2004 |
Externally published | Yes |
Keywords
- Coronary diseases
- Gene polymorphism
- Intercellular adhesion molecule-1
- Restenosis
- Stents
ASJC Scopus subject areas
- General Medicine