Polymers to treat brain tumours

Henry Brem

doi:10.1016/0142-9612(90)90030-T

Polymers to treat brain tumours

Henry Brem

School of Medicine

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Brain tumours are difficult to treat by conventional methods. A biodegradable polymer, poly-[bis(p-carboxyphenoxy) propane sebacic acid] with a nitrosourea, carmustine, has been demonstrated to be biocompatible in the brains of experimental animals and to release drugs in a predictable sustained manner. Carmustine impregnated in polymers appears to be more effective than when delivered by standard methods. A Phase I clinical study has demonstrated the safety of this approach in treating brain tumours and a Phase III placebo-controlled study is currently underway. Other applications of the polymer in the treatment of brain diseases are discussed.

Original language	English (US)
Pages (from-to)	699-701
Number of pages	3
Journal	Biomaterials
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/0142-9612(90)90030-T
State	Published - Nov 1990

Keywords

Drug delivery
biodegradation
carmustine
polyanhydrides

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/0142-9612(90)90030-T

Cite this

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title = "Polymers to treat brain tumours",

abstract = "Brain tumours are difficult to treat by conventional methods. A biodegradable polymer, poly-[bis(p-carboxyphenoxy) propane sebacic acid] with a nitrosourea, carmustine, has been demonstrated to be biocompatible in the brains of experimental animals and to release drugs in a predictable sustained manner. Carmustine impregnated in polymers appears to be more effective than when delivered by standard methods. A Phase I clinical study has demonstrated the safety of this approach in treating brain tumours and a Phase III placebo-controlled study is currently underway. Other applications of the polymer in the treatment of brain diseases are discussed.",

keywords = "Drug delivery, biodegradation, carmustine, polyanhydrides",

author = "Henry Brem",

note = "Funding Information: The author is appreciative for the assistance given by Rafael Tamargo, Alessandro Olivi, Carla Reinhard, Michael Pinn, Mark Chasin, Pamela Talalay and Elizabeth Collevecchio. This work is supported in part by National Institutes of Health grant no. 5K08-NS01058, Andrew W. Mellon Foundation Grant for Faculty Development, Johns Hopkins University School of Medicineand Nova Pharmaceuti~l Corporation.",

year = "1990",

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doi = "10.1016/0142-9612(90)90030-T",

language = "English (US)",

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AU - Brem, Henry

N1 - Funding Information: The author is appreciative for the assistance given by Rafael Tamargo, Alessandro Olivi, Carla Reinhard, Michael Pinn, Mark Chasin, Pamela Talalay and Elizabeth Collevecchio. This work is supported in part by National Institutes of Health grant no. 5K08-NS01058, Andrew W. Mellon Foundation Grant for Faculty Development, Johns Hopkins University School of Medicineand Nova Pharmaceuti~l Corporation.

PY - 1990/11

Y1 - 1990/11

N2 - Brain tumours are difficult to treat by conventional methods. A biodegradable polymer, poly-[bis(p-carboxyphenoxy) propane sebacic acid] with a nitrosourea, carmustine, has been demonstrated to be biocompatible in the brains of experimental animals and to release drugs in a predictable sustained manner. Carmustine impregnated in polymers appears to be more effective than when delivered by standard methods. A Phase I clinical study has demonstrated the safety of this approach in treating brain tumours and a Phase III placebo-controlled study is currently underway. Other applications of the polymer in the treatment of brain diseases are discussed.

AB - Brain tumours are difficult to treat by conventional methods. A biodegradable polymer, poly-[bis(p-carboxyphenoxy) propane sebacic acid] with a nitrosourea, carmustine, has been demonstrated to be biocompatible in the brains of experimental animals and to release drugs in a predictable sustained manner. Carmustine impregnated in polymers appears to be more effective than when delivered by standard methods. A Phase I clinical study has demonstrated the safety of this approach in treating brain tumours and a Phase III placebo-controlled study is currently underway. Other applications of the polymer in the treatment of brain diseases are discussed.

KW - Drug delivery

KW - biodegradation

KW - carmustine

KW - polyanhydrides

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Polymers to treat brain tumours

Abstract

Keywords

ASJC Scopus subject areas

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