Polydipsia and chronic hyponatremia in schizophrenic inpatients

D. G. Kirch, L. B. Bigelow, D. R. Weinberger, W. B. Lawson, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


The occasional presence of polydipsia in psychiatric patients, at times progressing to hyponatremia with severe medical complications, has been previously noted. The clinical history and laboratory data from eight chronically hyponatremic psychiatric inpatients were examined. Common characteristics were a diagnosis of chronic undifferentiated schizophrenia, an early age of onset of their illness, extended hospitalizations with minimal response to neuroleptic medications, heavy tobacco use, and a relatively high frequency of tardive dyskinesia and brain scan abnormalities. Water loading in three patients showed responses consistent with inappropriate secretion of antidiuretic hormone. Potential pathophysiologic mechanisms and treatment considerations are discussed.

Original languageEnglish (US)
Pages (from-to)179-181
Number of pages3
JournalJournal of Clinical Psychiatry
Issue number5
StatePublished - Sep 4 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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