Abstract
Background: PC1 and PC2 function as a complex, but their interrelations are not completely understood. Results: Expression of PC1 accelerates degradation of PC2. Conclusion: PC1 negatively regulates PC2 expression, presumptively by enhancing degradation via the aggresome/autophagosome pathway. Significance: Understanding how PC1 regulates PC2 within a critical range may help elucidate the pathogenesis of cyst formation.
Original language | English (US) |
---|---|
Pages (from-to) | 6404-6414 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 10 |
DOIs | |
State | Published - Mar 7 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology