POLYAMINE TURNOVER IN DIFFERENT REGIONS OF RAT BRAIN

E. G. Shaskan; S. H. Snyder

doi:10.1111/j.1471-4159.1973.tb00257.x

POLYAMINE TURNOVER IN DIFFERENT REGIONS OF RAT BRAIN

E. G. Shaskan, S. H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The dynamics of the formation and disappearance of polyamines in rat brain have been examined after intraventricular administration of a tracer dose of [³H]putrescine. After 2 days [³H]putrescine was no longer detectable in any brain region examined. [³H] Spermidine and [³H] spermine were formed in all brain areas. In the midbrain, hypothalamus and cerebellum (regions which manifested the greatest initial accumulation of tritium) the specific radioactivity of spermidine declined with a half‐life of 16‐19 days. However, in areas with a low initial accumulation of tritium (the medulla‐pons, internal capsule, cerebral cortex and corpus striatum) the specific radioactivity of spermidine changed very little between 2 and 19 days after the putrescine administration. Levels of [³H]spermine increased continuously in all brain areas for a 14‐day period after the putrescine injection.

Original language	English (US)
Pages (from-to)	1453-1460
Number of pages	8
Journal	Journal of Neurochemistry
Volume	20
Issue number	5
DOIs	https://doi.org/10.1111/j.1471-4159.1973.tb00257.x
State	Published - May 1973

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1973.tb00257.x

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title = "POLYAMINE TURNOVER IN DIFFERENT REGIONS OF RAT BRAIN",

abstract = "The dynamics of the formation and disappearance of polyamines in rat brain have been examined after intraventricular administration of a tracer dose of [3H]putrescine. After 2 days [3H]putrescine was no longer detectable in any brain region examined. [3H] Spermidine and [3H] spermine were formed in all brain areas. In the midbrain, hypothalamus and cerebellum (regions which manifested the greatest initial accumulation of tritium) the specific radioactivity of spermidine declined with a half‐life of 16‐19 days. However, in areas with a low initial accumulation of tritium (the medulla‐pons, internal capsule, cerebral cortex and corpus striatum) the specific radioactivity of spermidine changed very little between 2 and 19 days after the putrescine administration. Levels of [3H]spermine increased continuously in all brain areas for a 14‐day period after the putrescine injection.",

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POLYAMINE TURNOVER IN DIFFERENT REGIONS OF RAT BRAIN

Abstract

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