TY - JOUR
T1 - Poly(ADP-ribose)
T2 - An organizer of cellular architecture
AU - Leung, Anthony K.L.
PY - 2014
Y1 - 2014
N2 - Distinct properties of poly(ADP-ribose)-including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature-could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADPribose) could direct cellular organization.
AB - Distinct properties of poly(ADP-ribose)-including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature-could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADPribose) could direct cellular organization.
UR - http://www.scopus.com/inward/record.url?scp=84902322535&partnerID=8YFLogxK
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U2 - 10.1083/jcb.201402114
DO - 10.1083/jcb.201402114
M3 - Comment/debate
C2 - 24914234
AN - SCOPUS:84902322535
SN - 0021-9525
VL - 205
SP - 613
EP - 619
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 5
ER -