@inbook{992af9645b9e4522936c1221bd7c604c,
title = "Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases",
abstract = "Disruption of cellular functions with aging-induced accumulation of neuronal stressors causes cell death which is a common feature of neurodegenerative diseases. Studies in a variety of neurodegenerative disease models demonstrate that poly (ADP-ribose) (PAR)-dependent cell death, also named parthanatos, is responsible for neuronal loss in neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Parthanatos has distinct features that differ from caspase-dependent apoptosis, necrosis or autophagic cell death. Parthanatos can be triggered by the accumulation of PAR due to overactivation of PAR polymerase-1 (PARP-1). Excess PAR, induces the mitochondrial release apoptosis-inducing factor (AIF), which binds to macrophage migration inhibitory factor (MIF) carrying MIF into the nucleus where it cleaves genomic DNA into large fragments. In this review, we will discuss the molecular mechanisms of parthanatos and their role in neurodegenerative diseases. Furthermore, we will discuss promising therapeutic interventions within the pathological PAR signaling cascade that could be designed to halt the progression of neurodegeneration.",
keywords = "AIF, Cell death, MIF, Neurodegenerative disease, PAR, PARP-1, Parthanatos, Poly (ADP-ribose)",
author = "Hyejin Park and Kam, {Tae In} and Dawson, {Ted M.} and Dawson, {Valina L.}",
note = "Funding Information: We would like to thank Dr. Jennifer Roshek and Ms. Elizabeth Wilmarth for editorial assistance. This work was supported by US National Institutes of Health grants NS38377, NS67525 and by the JPB Foundation. The authors acknowledge the joint participation by the Adrienne Helis Malvin Medical Research Foundation through its direct engagement in the continuous active conduct of medical research in conjunction with the Johns Hopkins Hospital and the Johns Hopkins University School of Medicine and the Foundation's Parkinson's Disease Programs M-2016. The authors thank I-Hsun Wu for assistance with the illustrations. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
doi = "10.1016/bs.ircmb.2019.12.009",
language = "English (US)",
isbn = "9780128201350",
series = "International Review of Cell and Molecular Biology",
publisher = "Elsevier Inc.",
pages = "1--29",
editor = "Spetz, {Johan K.E.} and Lorenzo Galluzzi",
booktitle = "Cell Death Regulation In Health And Disease - Part C",
}