@article{0eda7ffd5ca844aa943a5af3ee9c56fb,
title = "Point-of-care molecular diagnostics for the detection of group A Streptococcus in non-invasive skin and soft tissue infections: a validation study",
abstract = "Background: Skin and soft tissue infections (SSTIs) are commonly caused by group A Streptococcus (GAS). Rapid molecular assays for detecting GAS in wounds would help with clinical management. This study assessed a point-of-care system for the detection of GAS in non-severe SSTIs in a Native American community in the Southwest. Methods: Patients presenting with a new non-severe SSTI were eligible if a swab was collected. The swab was tested by traditional culture methods and using the cobas{\textregistered} Liat{\textregistered} point-of-care (POC) system and results were compared. Results: 399 samples were included. The final result from the POC assay was positive for 52.0% of samples. Compared to culture, the POC assay had a sensitivity of 100% and specificity of 99.5%. Conclusions: The cobas{\textregistered} Liat{\textregistered} system accurately and efficiently identified GAS in non-severe SSTIs. Having a POC test available to rapidly identify or rule out GAS could help to minimize overuse of antibiotics.",
keywords = "Group A Streptococcus, Native Americans, diagnostics, skin and soft tissue infections",
author = "Close, {Ryan M.} and Sutcliffe, {Catherine G.} and Patrick Galdun and Angelina Reid and Askew, {Morgan R.} and Davidson, {Anne M.} and Kamellia Kellywood and Dennie Parker and Jayshree Patel and Eugene Romancito and Brown, {Laura B.} and McAuley, {James B.} and Hammitt, {Laura L.}",
note = "Funding Information: The authors thank the staff at the Center for American Indian Health and the clinical and laboratory staff at the Whiteriver Service Unit for their assistance in conducting the study. The authors also thank the White Mountain Apache Tribe for their support of the study. This work was supported by an Investigator Initiated Clinical Study Award from Roche Molecular Systems, Inc (grant # 130341 awarded to Dr. Laura Hammitt). Any opinions, findings, conclusions, or recommendations expressed are those of the authors and do not represent the policy or position of Roche Molecular Systems, Inc. The sponsor had no role in the analysis of the data, writing of the manuscript, or the decision to submit the manuscript for publication. Ryan M Close: Conceptualization, Supervision, Project administration, Formal analysis, Writing – Original Draft. Catherine G Sutcliffe: Conceptualization, Supervision, Data Curation, Formal analysis, Writing – Original Draft. Patrick Galdun: Data Curation, Formal analysis, Writing – Review & Editing. Angelina Reid: Investigation, Writing – Review & Editing. Morgan R Askew: Investigation, Writing – Review & Editing. Anne M Davidson: Investigation, Writing – Review & Editing. Kamellia Kellywood: Investigation, Writing – Review & Editing. Dennie Parker: Investigation, Writing – Review & Editing. Laura B Brown: Project administration, Writing – Review & Editing. Jayshree Patel: Resources, Writing – Review & Editing. Eugene Romancito: Resources, Writing – Review & Editing. James B McAuley: Conceptualization, Writing – Review & Editing. Laura L Hammitt: Conceptualization, Funding acquisition, Supervision, Writing – Review & Editing. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = aug,
doi = "10.1016/j.diagmicrobio.2022.115729",
language = "English (US)",
volume = "103",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "4",
}