Podocytes are nonhematopoietic professional antigen-presenting cells

Andreas Goldwich, Miriam Burkard, Martha Ölke, Christoph Daniel, Kerstin Amann, Christian Hugo, Christian Kurts, Alexander Steinkasserer, André Gessner

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Podocytes are essential to the structure and function of the glomerular filtration barrier; however, they also exhibit increased expression of MHC class II molecules under inflammatory conditions, and they remove Ig and immune complexes from the glomerular basement membrane (GBM). This finding suggests that podocytes may act as antigen-presenting cells, taking up and processing antigens to initiate specific T cell responses, similar to professional hematopoietic cells such as dendritic cells or macrophages. Here, MHC- antigen complexes expressed exclusively on podocytes of transgenic mice were sufficient to activate CD8+ T cells in vivo. In addition, deleting MHC class II exclusively on podocytes prevented the induction of experimental anti-GBM nephritis. Podocytes ingested soluble and particulate antigens, activated CD4+ T cells, and crosspresented exogenous antigen on MHC class I molecules to CD8+ T cells. In conclusion, podocytes participate in the antigen-specific activation of adaptive immune responses, providing a potential target for immunotherapies of inflammatory kidney diseases and transplant rejection.

Original languageEnglish (US)
Pages (from-to)906-916
Number of pages11
JournalJournal of the American Society of Nephrology
Issue number6
StatePublished - May 31 2013
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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