Pneumocystis carinii pneumonia in children infected with the human immunodeficiency virus

W. J. Moss, C. Donahue, E. Abrams

Research output: Contribution to journalArticlepeer-review


The initial episode of Pneumocystis carinii pneumonia (PCP) in eighteen children with perinatally acquired human immunodeficiency virus (HIV) infects is described. In seven infants PCP was the presenting manifestation of HIV infection. Three children developed Pneumocystis pneumonia while receiving prophylactic therapy, but in two the duration of therapy was suboptimal and the third was not compliant. The Centers for Disease Control and Prevention (CDC) guidelines for PCP prophylaxis would have identified all children except one as requiring PCP prophylaxis based on CD4 T-lymphocyte cell counts. Corticosteroid therapy did appear not to improve survival in this small, nonrandomized cohort of patients. Early detection of HIV infection and the early institution of prophylactic therapy can be expected to improve the survival of HIV-infected children.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalPediatric AIDS and HIV infection
Issue number2
StatePublished - May 25 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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